The ability of biological systems to tightly regulate targeted variables, despite external and
internal disturbances, is known as Robust Perfect Adaptation (RPA). Achieved frequently …

The regulation of cellular dynamics and responses to stimuli by genetic regulatory networks
suggests how in vitro chemical reaction networks might analogously direct the dynamics of …

Synthetic biology integrates diverse engineering disciplines to create novel biological
systems for biomedical and technological applications. The substantial growth of the …

Cells, the fundamental units of life, orchestrate intricate functions—motility, adaptation,
replication, communication, and self-organization within tissues. Originating from …

We describe a framework for designing the sequences of multiple nucleic acid strands
intended to hybridize in solution via a prescribed reaction pathway. Sequence design is …

The design of synthetic circuits for controlling molecular-scale processes is an important
goal of synthetic biology, with potential applications in future in vitro and in vivo …

Feedback regulation is pervasive in biology at both the organismal and cellular level. In this
article, we explore the properties of a particular biomolecular feedback mechanism called …

Biomolecular control enables leveraging cells as biomanufacturing factories. Despite recent
advancements, we currently lack genetically encoded modules that can be deployed to …

Engineered far-from-equilibrium synthetic chemical networks that pulse or switch states in
response to environmental signals could precisely regulate the kinetics of chemical …

Feedback control has enabled the success of automated technologies by mitigating the
effects of variability, unknown disturbances, and noise. While it is known that biological …