Contrary to the long-held view that most humans harbour only identical mitochondrial
genomes, deep resequencing has uncovered unanticipated extreme genetic variation within …

Common genetic variants of mitochondrial DNA (mtDNA) increase the risk of developing
several of the major health issues facing the western world, including neurodegenerative …

Once considered exclusively the cell's powerhouse, mitochondria are now recognized to
perform multiple essential functions beyond energy production, impacting most areas of cell …

Mammalian genes were long thought to be constrained within somatic cells in most cell
types. This concept was challenged recently when cellular organelles including …

Mitochondria are a distinguishing feature of eukaryotic cells. Best known for their critical
function in energy production via oxidative phosphorylation (OXPHOS), mitochondria are …

Heteroplasmy in human mtDNA may play a role in cancer, other diseases, and aging, but
patterns of heteroplasmy variation across different tissues have not been thoroughly …

Replacement of mitochondria through nuclear transfer between oocytes of two different
women has emerged recently as a strategy for preventing inheritance of mtDNA diseases …

Cell-to-cell heterogeneity drives a range of (patho) physiologically important phenomena,
such as cell fate and chemotherapeutic resistance. The role of metabolism, and particularly …

The aim of this review was to provide an evidence-based approach to frequently asked
questions relating to the risk of transmitting a maternally inherited mitochondrial disorder …

Inheritance of the mitochondrial genome does not follow the rules of conventional
Mendelian genetics. The mitochondrial DNA (mtDNA) is present in many copies per cell and …