E2F family of transcription factors regulates various cellular functions related to cell cycle
and apoptosis. Its individual members have traditionally been classified into activators and …

B-Myb is an important transcription factor that plays a critical role in gene expression
regulation and tumorigenesis. However, its functional implication in colorectal cancer …

Gastric cancer (GC) is the second most frequent cause of cancer-related mortality in the
world, with Eastern Asia having the highest incidence rates. E2F is a family of transcription …

Growing evidence has revealed that the E2F family of transcription factor 2 (E2F2)
participates in the tumorigenesis and progression of various tumors, but its role in colorectal …

E2F transcription factors regulate a wide range of biological processes, including cell cycle,
apoptosis and DNA damage response. In the present study, we examined whether E2F2 is …

Recently, RBM15 has emerged as an oncogenic factor in a majority of tumors. However, the
mechanism is unclear that accounts for how RBM15‐induces colorectal cancer (CRC) …

Many human cancers present Phosphatase and tensin homolog (PTEN) deficiency and
between 20 and 30% of colorectal tumors show PTEN loss. The transcription factor, E2 …

Purpose: Colorectal cancer (CRC) is the 3rd most prevalent malignant tumour globally.
Although significant strides have been made in diagnosis and treatment, its prognosis at the …

Hereditary familial adenomatous polyposis (FAP) in humans significantly increases the risk
of development of colorectal cancer (CRC). Germline mutations in the APC (adenomatous …

Background E2Fs are important components of transcription factors and play key roles in
occurrence or advancement of various cancers, but the expression and exact roles of each …