Retinoids (vitamin A) are crucial for most forms of life. In chordates, they have important roles
in the developing nervous system and notochord and many other embryonic structures, as …

The key role of vitamin A in embryonal development is reviewed. Special emphasis is given
to the physiological action of retinoids, as evident from the retinoid ligand knockout models …

An important requirement for physiologic homeostasis is the detoxification and removal of
endogenous hormones and xenobiotic compounds with biological activity. Much of the …

The vitamins are a chemically disparate group of compounds whose only common feature is
that they are dietary essentials that are required in small amounts for the normal functioning …

Retinoids are ubiquitous signaling molecules that influence nearly every cell type, exert
profound effects on development, and complement cancer chemotherapeutic regimens. All …

Dietary and xenobiotic compounds can disrupt endocrine signaling, particularly of steroid
receptors and sexual differentiation. Evidence is also mounting that implicates …

Vitamin A (all-trans-retinol, 1, Figure 1) is considered the most multifunctional vitamin in the
human body. 1 It plays key roles in many physiological processes such as vision …

Members of the nuclear-receptor superfamily mediate crucial physiological functions by
regulating the synthesis of their target genes. Nuclear receptors are usually activated by …

Vitamin A and related retinoids play an important role in the regulation of immune function.
Vitamin A deficiency compromises immunity, resulting in major morbidity and mortality. The …

Retinoic acid (RA) metabolites of vitamin A are key regulators of gene expression involved
in embryonic development and maintenance of epithelial tissues. The cellular effects of RA …