Type 1 diabetes mellitus (T1D) is a chronic disease characterized by an autoimmune
destruction of insulin-producing β-pancreatic cells. Although many advances have been …

Type 1 diabetes mellitus (T1DM) is the most common chronic autoimmune disease in young
patients and is characterized by the loss of pancreatic β cells; as a result, the body becomes …

Understanding the biology underlying the mechanisms and pathways regulating pancreatic
β cell development is necessary to understand the pathology of diabetes mellitus (DM) …

Human embryonic stem cells (hESC) and induced pluripotent stem cells (hiPSC) are
considered attractive sources of pancreatic β cells and islet organoids. Recently, several …

Diabetes mellitus (DM) is one of the most prevalent metabolic disorders. In order to replace
the function of the destroyed pancreatic beta cells in diabetes, islet transplantation is the …

COVID-19 pandemic has infected more than 154 million people worldwide and caused
more than 3.2 million deaths. It is transmitted by the Severe Acute Respiratory Syndrome …

Studies on diabetes have long been hampered by a lack of authentic disease models that,
ideally, should be unlimited and able to recapitulate the abnormalities involved in the …

Aims/hypothesis Homozygous mutations in RFX6 lead to neonatal diabetes accompanied
by a hypoplastic pancreas, whereas heterozygous mutations cause MODY. Recent studies …

Recently, fibroblast growth factors are identified to play a vital role in the development and
progression of human pancreatic cancer. FGF pathway is critical involved in numerous …

Psoriasis is characterized by hyperproliferation and defective differentiation of keratinocytes
(KCs). Patients with psoriasis are at a high risk of developing diabetes and cardiovascular …