[HTML][HTML] Challenges and opportunities in modelling wet granulation in pharmaceutical industry–a critical review

M Singh, S Shirazian, V Ranade, GM Walker… - Powder Technology, 2022 - Elsevier
Wet granulation is a key step in the pharmaceutical manufacturing of solid-dosage forms.
Wet granulation is used in pharmaceutical production to enhance formulation qualities such …

Challenges and opportunities concerning numerical solutions for population balances: a critical review

M Singh, V Ranade, O Shardt… - Journal of Physics A …, 2022 - iopscience.iop.org
Population balance models are tools for the study of dispersed systems, such as granular
materials, polymers, colloids and aerosols. They are applied with increasing frequency …

Accurate and efficient approximations for generalized population balances incorporating coagulation and fragmentation

M Singh - Journal of Computational Physics, 2021 - Elsevier
This study focuses on development of two approaches based on finite volume schemes for
solving both one-dimensional and multidimensional nonlinear simultaneous coagulation …

Discrete finite volume approach for multidimensional agglomeration population balance equation on unstructured grid

M Singh, R Singh, S Singh, G Walker, T Matsoukas - Powder Technology, 2020 - Elsevier
In this work, a discrete finite volume scheme (FVS) is developed for approximating a
multidimensional agglomeration population balance equation on an unstructured grid …

Improvement of a 1d population balance model for twin-screw wet granulation by using identifiability analysis

AA Barrera Jiménez, D Van Hauwermeiren, M Peeters… - Pharmaceutics, 2021 - mdpi.com
Recently, the pharmaceutical industry has undergone changes in the production of solid oral
dosages from traditional inefficient and expensive batch production to continuous …

Characterization of simultaneous evolution of size and composition distributions using generalized aggregation population balance equation

M Singh, A Kumar, S Shirazian, V Ranade, G Walker - Pharmaceutics, 2020 - mdpi.com
The application of multi-dimensional population balance equations (PBEs) for the simulation
of granulation processes is recommended due to the multi-component system. Irrespective …

Finite volume approximation of nonlinear agglomeration population balance equation on triangular grid

M Singh, HY Ismail, R Singh, AB Albadarin… - Journal of Aerosol …, 2019 - Elsevier
In this present work, a finite volume scheme for approximating a multidimensional nonlinear
agglomeration population balance equation on a regular triangular grid is developed. The …

Biomineral flocculation of kaolinite and microalgae: Laboratory experiments and stochastic modeling

Y Zhu, M Lin, X Shen, M Fettweis… - Journal of …, 2022 - Wiley Online Library
In estuaries and coastal waters, the flocculation of cohesive sediments is significantly
affected by extracellular polymeric substances secreted by microalgae. In this study …

[HTML][HTML] Discrete finite volume formulation for multidimensional fragmentation equation and its convergence analysis

M Singh, T Matsoukas, V Ranade, G Walker - Journal of Computational …, 2022 - Elsevier
The present work is focused on developing a finite volume scheme for a multidimensional
fragmentation equation. The finite volume scheme is established using the concept of …

Effect of different discretizations on the numerical solution of 2D aggregation population balance equation

M Singh, K Vuik, G Kaur, HJ Bart - Powder Technology, 2019 - Elsevier
This work is concerned with the assessment of the various discretizations used to obtain the
numerical solutions of the bivariate aggregation population balance equation. It was …