SARS-CoV-2-specific immune response and the pathogenesis of COVID-19

E Gusev, A Sarapultsev, L Solomatina… - International journal of …, 2022 - mdpi.com
The review aims to consolidate research findings on the molecular mechanisms and
virulence and pathogenicity characteristics of coronavirus disease (COVID-19) causative …

Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)

X Xu, KL Poulsen, L Wu, S Liu, T Miyata… - Signal transduction and …, 2022 - nature.com
Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …

ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities

N Zamorano Cuervo, N Grandvaux - elife, 2020 - elifesciences.org
Pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
coronavirus 19 disease (COVID-19) which presents a large spectrum of manifestations with …

COVID-19 spike-host cell receptor GRP78 binding site prediction

IM Ibrahim, DH Abdelmalek, ME Elshahat, AA Elfiky - Journal of infection, 2020 - Elsevier
Objectives Understanding the novel coronavirus (COVID-19) mode of host cell recognition
may help to fight the disease and save lives. The spike protein of coronaviruses is the main …

Antiviral activity of green tea and black tea polyphenols in prophylaxis and treatment of COVID-19: A review

S Mhatre, T Srivastava, S Naik, V Patravale - Phytomedicine, 2021 - Elsevier
Background The rapid spread of novel coronavirus called SARS-CoV-2 or nCoV has caused
countries all over the world to impose lockdowns and undertake stringent preventive …

Natural products may interfere with SARS-CoV-2 attachment to the host cell

AA Elfiky - Journal of Biomolecular Structure and Dynamics, 2021 - Taylor & Francis
SARS-CoV-2 has been emerged in December 2019 in China, causing deadly (5% mortality)
pandemic pneumonia, termed COVID-19. More than one host-cell receptor is reported to be …

Obesity as a risk factor for severe COVID-19 and complications: a review

F Demeulemeester, K de Punder, M van Heijningen… - Cells, 2021 - mdpi.com
Emerging data suggest that obesity is a major risk factor for the progression of major
complications such as acute respiratory distress syndrome (ARDS), cytokine storm and …

Insights into SGLT2 inhibitor treatment of diabetic cardiomyopathy: focus on the mechanisms

K Huang, X Luo, B Liao, G Li, J Feng - Cardiovascular Diabetology, 2023 - Springer
Among the complications of diabetes, cardiovascular events and cardiac insufficiency are
considered two of the most important causes of death. Experimental and clinical evidence …

COVID-19-related hyperglycemia is associated with infection of hepatocytes and stimulation of gluconeogenesis

EA Barreto, AS Cruz, FP Veras… - Proceedings of the …, 2023 - National Acad Sciences
Occurrence of hyperglycemia upon infection is associated with worse clinical outcome in
COVID-19 patients. However, it is still unknown whether SARS-CoV-2 directly triggers …

Endoplasmic reticulum stress and the unfolded protein response in cerebral ischemia/reperfusion injury

L Wang, Y Liu, X Zhang, Y Ye, X Xiong… - Frontiers in Cellular …, 2022 - frontiersin.org
Ischemic stroke is an acute cerebrovascular disease characterized by sudden interruption of
blood flow in a certain part of the brain, leading to serious disability and death. At present …