Cellular and molecular mechanisms associating obesity to bone loss

YS Forte, M Renovato-Martins, C Barja-Fidalgo - Cells, 2023 - mdpi.com
Obesity is an alarming disease that favors the upset of other illnesses and enhances
mortality. It is spreading fast worldwide may affect more than 1 billion people by 2030. The …

Inflammation: a putative link between phosphate metabolism and cardiovascular disease

J Voelkl, D Egli-Spichtig, I Alesutan… - Clinical Science, 2021 - portlandpress.com
Dietary habits in the western world lead to increasing phosphate intake. Under physiological
conditions, extraosseous precipitation of phosphate with calcium is prevented by a mineral …

New aspects of the kidney in the regulation of fibroblast growth factor 23 (FGF23) and mineral homeostasis

ML Mace, K Olgaard, E Lewin - International journal of molecular sciences, 2020 - mdpi.com
The bone-derived hormone fibroblast growth factor 23 (FGF23) acts in concert with
parathyroid hormone (PTH) and the active vitamin D metabolite calcitriol in the regulation of …

Upstream regulators of fibroblast growth factor 23

DMA Ratsma, MC Zillikens… - Frontiers in …, 2021 - frontiersin.org
Fibroblast growth factor 23 (FGF23) has been described as an important regulator of mineral
homeostasis, but has lately also been linked to iron deficiency, inflammation, and …

FGF23 in chronic kidney disease: bridging the heart and anemia

A Figurek, M Rroji, G Spasovski - Cells, 2023 - mdpi.com
Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone produced mainly in
osteocytes. In chronic kidney disease (CKD) FGF23 levels increase due to higher …

[PDF][PDF] Phosphate restriction prevents metabolic acidosis and curbs rise in FGF23 and mortality in murine folic acid-induced AKI

AK Hamid, EMP Arroyo, C Calvet… - Journal of the …, 2024 - journals.lww.com
Background: In acute kidney injury (AKI), plasma fibroblast growth factor 23 (FGF23) and
phosphate (P i) rise rapidly and are independently associated with disease severity and …

Bone marrow sinusoidal endothelial cells are a site of Fgf23 upregulation in a mouse model of iron deficiency anemia

X Li, L Lozovatsky, SM Tommasini, J Fretz… - Blood …, 2023 - ashpublications.org
Iron deficiency is a potent stimulator of fibroblast growth factor 23 (FGF23), a hormonal
regulator of phosphate and vitamin D metabolism, that is classically thought to be produced …

[HTML][HTML] Roles of fibroblast growth factors in the treatment of diabetes

CY Zhang, M Yang - World Journal of Diabetes, 2024 - ncbi.nlm.nih.gov
Diabetes affects about 422 million people worldwide, causing 1.5 million deaths each year.
However, the incidence of diabetes is increasing, including several types of diabetes. Type 1 …

The role of alterations in alpha-Klotho and FGF-23 in kidney transplantation and kidney donation

M Gupta, G Orozco, M Rao, R Gedaly… - Frontiers in …, 2022 - frontiersin.org
Cardiovascular disease and mineral bone disorders are major contributors to morbidity and
mortality among patients with chronic kidney disease and often persist after renal …

Targeting aging with the healthy skeletal system: The endocrine role of bone

XQ Zheng, JL Lin, J Huang, T Wu, CL Song - Reviews in Endocrine and …, 2023 - Springer
Aging is an inevitable biological process, and longevity may be related to bone health.
Maintaining strong bone health can extend one's lifespan, but the exact mechanism is …