One of the most striking hallmarks shared by various neurodegenerative diseases, including
Parkinson's disease, Alzheimer's disease (AD), and amyotrophic lateral sclerosis, is …

An understanding of the structural complexity of mineralised tissues is fundamental for
exploration into the field of diagenesis. Here we review aspects of current and past research …

Collagens are the most abundant high molecular weight proteins in both invertebrate and
vertebrate organisms, including mammals, and possess mainly a structural role, existing …

Collagen is the most abundant protein in animals. This fibrous, structural protein comprises
a right-handed bundle of three parallel, left-handed polyproline II-type helices. Much …

Posttranslational modifications can cause profound changes in protein function. Typically,
these modifications are reversible, and thus provide a biochemical on-off switch. In contrast …

Many cosmetic formulations have collagen as a major component because of its significant
benefits as a natural humectant and moisturizer. This industry is constantly looking for …

Within the canonical repertoire of the amino acid involved in protein biogenesis, proline
plays a unique role as an amino acid presenting a modified backbone rather than a side …

The molecular conformation of the collagen triple helix confers strict amino acid sequence
constraints, requiring a (Gly-XY) n repeating pattern and a high content of imino acids. The …

2-Oxoglutarate (2OG) dependent oxygenases are ubiquitous iron enzymes that couple
substrate oxidation to the conversion of 2OG to succinate and carbon dioxide. In humans …

Prolyl hydroxylation is a critical posttranslational modification that affects structure, function,
and turnover of target proteins. Prolyl 3-hydroxylation occurs at only one position in the triple …