The C Factor: Cognitive dysfunction as a transdiagnostic dimension in psychopathology

A Abramovitch, T Short, A Schweiger - Clinical Psychology Review, 2021 - Elsevier
Research into cognitive functions across psychological disorders suggests that cognitive
deficiencies may be present across multiple disorders, potentially pointing to a …

The biology and pathobiology of glutamatergic, cholinergic, and dopaminergic signaling in the aging brain

A Gasiorowska, M Wydrych, P Drapich… - Frontiers in aging …, 2021 - frontiersin.org
The elderly population is growing worldwide, with important health and socioeconomic
implications. Clinical and experimental studies on aging have uncovered numerous …

Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking

AE Lepack, CT Werner, AF Stewart, SL Fulton, P Zhong… - Science, 2020 - science.org
Vulnerability to relapse during periods of attempted abstinence from cocaine use is
hypothesized to result from the rewiring of brain reward circuitries, particularly ventral …

The mesolimbic dopamine system in chronic pain and associated affective comorbidities

RA Serafini, KD Pryce, V Zachariou - Biological psychiatry, 2020 - Elsevier
Chronic pain is a complex neuropsychiatric disorder characterized by sensory, cognitive,
and affective symptoms. Over the past 2 decades, researchers have made significant …

The case for TAAR1 as a modulator of central nervous system function

G Rutigliano, A Accorroni, R Zucchi - Frontiers in pharmacology, 2018 - frontiersin.org
TAAR1 is widely expressed across the mammalian brain, particularly in limbic and
monoaminergic areas, allegedly involved in mood, attention, memory, fear, and addiction …

Molecular neurobiology of addiction

EJ Nestler - American Journal on Addictions, 2001 - Taylor & Francis
Addiction can be viewed as a form of drug-induced neural plasticity. One of the best
established molecular mechanisms of addiction is the upregulation of the cAMP second …

Microglia in neuroimmunopharmacology and drug addiction

H Li, LR Watkins, X Wang - Molecular Psychiatry, 2024 - nature.com
Drug addiction is a chronic and debilitating disease that is considered a global health
problem. Various cell types in the brain are involved in the progression of drug addiction …

N-oleoyl glycine and N-oleoyl alanine attenuate alcohol self-administration and preference in mice

S Shahen-Zoabi, R Smoum, A Bingor, E Grad… - Translational …, 2023 - nature.com
The endocannabinoid system (ECS) plays a key modulatory role during synaptic plasticity
and homeostatic processes in the brain and has an important role in the neurobiological …

Molecular genetics of cocaine use disorders in humans

N Fernandez-Castillo, J Cabana-Dominguez… - Molecular …, 2022 - nature.com
Drug addiction, one of the major health problems worldwide, is characterized by the loss of
control in drug intake, craving, and withdrawal. At the individual level, drugs of abuse …

The nucleus accumbens: A common target in the comorbidity of depression and addiction

L Xu, J Nan, Y Lan - Frontiers in neural circuits, 2020 - frontiersin.org
The comorbidity of depression and addiction has become a serious public health issue, and
the relationship between these two disorders and their potential mechanisms has attracted …