Cryo-electron microscopy of IgM-VAR2CSA complex reveals IgM inhibits binding of Plasmodium falciparum to Chondroitin Sulfate A
RR Akhouri, S Goel, U Skoglund - Nature Communications, 2023 - nature.com
Placental malaria is caused by Plasmodium falciparum-infected erythrocytes (IEs) adhering
to chondroitin sulfate proteoglycans in placenta via VAR2CSA-type PfEMP1. Human …
to chondroitin sulfate proteoglycans in placenta via VAR2CSA-type PfEMP1. Human …
Extracellular vesicles and epidermal growth factor receptor activation: interplay of drivers in cancer progression
E Ferlizza, D Romaniello, F Borrelli, F Pagano… - Cancers, 2023 - mdpi.com
Simple Summary Extracellular vesicles (EVs), consisting of microvesicles and exosomes,
serve as messengers for intercellular communication by transporting proteins and nucleic …
serve as messengers for intercellular communication by transporting proteins and nucleic …
[HTML][HTML] Biochemical Pathways Delivering Distinct Glycosphingolipid Patterns in MDA-MB-231 and MCF-7 Breast Cancer Cells
A Markotić, J Omerović, S Marijan… - Current Issues in …, 2024 - mdpi.com
The complex structure of glycosphingolipids (GSLs) supports their important role in cell
function as modulators of growth factor receptors and glutamine transporters in plasma …
function as modulators of growth factor receptors and glutamine transporters in plasma …
[PDF][PDF] Different EGF-induced receptor dimer conformations for signaling and internalization
J Haubrich, JM Zwier, F Charrier-Savournin, L Prézeau… - 2024 - repository.ubn.ru.nl
The structural basis of the activation and internalization of EGF receptors (EGFR) is still a
matter of debate despite the importance of this target in cancer treatment. Whether agonists …
matter of debate despite the importance of this target in cancer treatment. Whether agonists …
Self-inhibition of HER2 and HER3 at fever temperatures may prevent their hetero-dimerization
HER2 and HER3 receptors dimerize into potent pro-oncogenic complexes involved in
various aggressive and recurrent tumors. The role of febrile temperatures on the formation of …
various aggressive and recurrent tumors. The role of febrile temperatures on the formation of …
Self-inhibition of HER2 at fever temperatures may prevent dimerization with HER3
Background HER2 receptor is overexpressed in different aggressive and recurrent tumors,
and the modulation of its conformational changes has been achieved using immunotherapy …
and the modulation of its conformational changes has been achieved using immunotherapy …