The Diversity, Biogenesis, and Activities of Endogenous Silencing Small RNAs in Arabidopsis

NG Bologna, O Voinnet - Annual review of plant biology, 2014 - annualreviews.org
In eukaryotic RNA silencing, RNase-III classes of enzymes in the Dicer family process
double-stranded RNA of cellular or exogenous origin into small-RNA (sRNA) molecules …

miRNA biogenesis: a dynamic pathway

NP Achkar, DA Cambiagno, PA Manavella - Trends in Plant Science, 2016 - cell.com
MicroRNAs (miRNAs) modulate plant homeostasis through the inactivation of specific
mRNAs, especially those encoding transcription factors. A delicate spatial/temporal balance …

Mechanism of siRNA production by a plant Dicer-RNA complex in dicing-competent conformation

Q Wang, Y Xue, L Zhang, Z Zhong, S Feng, C Wang… - Science, 2021 - science.org
In eukaryotes, small RNAs (sRNAs) play critical roles in multiple biological processes. Dicer
endonucleases are a central part of sRNA biogenesis. In plants, DICER-LIKE PROTEIN 3 …

A one precursor one siRNA model for Pol IV-dependent siRNA biogenesis

J Zhai, S Bischof, H Wang, S Feng, T Lee, C Teng… - Cell, 2015 - cell.com
RNA-directed DNA methylation in Arabidopsis thaliana is driven by the plant-specific RNA
Polymerase IV (Pol IV). It has been assumed that a Pol IV transcript can give rise to multiple …

Identification of Pol IV and RDR2-dependent precursors of 24 nt siRNAs guiding de novo DNA methylation in Arabidopsis

T Blevins, R Podicheti, V Mishra, M Marasco, J Wang… - elife, 2015 - elifesciences.org
In Arabidopsis thaliana, abundant 24 nucleotide small interfering RNAs (24 nt siRNA) guide
the cytosine methylation and silencing of transposons and a subset of genes. 24 nt siRNA …

Plant dicer-like proteins: double-stranded RNA-cleaving enzymes for small RNA biogenesis

A Fukudome, T Fukuhara - Journal of Plant Research, 2017 - Springer
Dicer, a double-stranded RNA (dsRNA)-specific endoribonuclease, plays an essential role
in triggering both transcriptional and post-transcriptional gene silencing in eukaryotes by …

Dicer-independent RNA-directed DNA methylation in Arabidopsis

DL Yang, G Zhang, K Tang, J Li, L Yang, H Huang… - Cell research, 2016 - nature.com
RNA-directed DNA methylation (RdDM) is an important de novo DNA methylation pathway
in plants. Small interfering RNAs (siRNAs) generated by Dicers from RNA polymerase IV …

The plant siRNA landscape

H Vaucheret, O Voinnet - The Plant Cell, 2024 - academic.oup.com
Whereas micro (mi) RNAs are considered the clean, noble side of the small RNA world,
small interfering (si) RNAs are often seen as a noisy set of molecules whose barbarian …

Epigenetic gene regulation in plants and its potential applications in crop improvement

H Zhang, JK Zhu - Nature Reviews Molecular Cell Biology, 2024 - nature.com
DNA methylation, also known as 5-methylcytosine, is an epigenetic modification that has
crucial functions in plant growth, development and adaptation. The cellular DNA methylation …

Enzymatic reactions of AGO4 in RNA-directed DNA methylation: siRNA duplex loading, passenger strand elimination, target RNA slicing, and sliced target retention

F Wang, HY Huang, J Huang, J Singh… - Genes & …, 2023 - genesdev.cshlp.org
RNA-directed DNA methylation in plants is guided by 24-nt siRNAs generated in parallel
with 23-nt RNAs of unknown function. We show that 23-nt RNAs function as passenger …