Therapeutic approach to Alzheimer's disease: current treatments and new perspectives

T Pardo-Moreno, A González-Acedo… - Pharmaceutics, 2022 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia. The pathophysiology of
this disease is characterized by the accumulation of amyloid-β, leading to the formation of …

Current understanding of the physiopathology, diagnosis and therapeutic approach to Alzheimer's disease

V García-Morales, A González-Acedo… - Biomedicines, 2021 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia. It is characterized by
cognitive decline and progressive memory loss. The aim of this review was to update the …

[HTML][HTML] The role of melatonin in the treatment of type 2 diabetes mellitus and Alzheimer's disease

S Shen, Q Liao, YK Wong, X Chen, C Yang… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
In type 2 diabetes mellitus (T2DM) and its related disorders like obesity, the abnormal
protein processing, oxidative stress and proinflammatory cytokines will drive the activation of …

Link between diabetes and Alzheimer's disease due to the shared amyloid aggregation and deposition involving both neurodegenerative changes and neurovascular …

GD Stanciu, V Bild, DC Ababei, RN Rusu… - Journal of Clinical …, 2020 - mdpi.com
Diabetes and Alzheimer's disease are two highly prevalent diseases among the aging
population and have become major public health concerns in the 21st century, with a …

[HTML][HTML] Gut-brain axis through the lens of gut microbiota and their relationships with Alzheimer's disease pathology: review and recommendations

L Krishaa, TKS Ng, HN Wee, J Ching - Mechanisms of Ageing and …, 2023 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder that affects millions of people
worldwide. Growing evidence suggests that the gut microbiome (GM) plays a pivotal role in …

Alzheimer's disease and diabetes: Role of diet, microbiota and inflammation in preclinical models

MJ Carranza-Naval, M Vargas-Soria… - Biomolecules, 2021 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia. Epidemiological studies
show the association between AD and type 2 diabetes (T2DM), although the mechanisms …

[HTML][HTML] Metabolic perspective of astrocyte dysfunction in Alzheimer's disease and type 2 diabetes brains

Z Shen, ZY Li, MT Yu, KL Tan, S Chen - Biomedicine & pharmacotherapy, 2023 - Elsevier
The term type III diabetes (T3DM) has been proposed for Alzheimer's disease (AD) due to
the shared molecular and cellular features between type 2 diabetes (T2DM) and insulin …

Liraglutide reduces vascular damage, neuronal loss, and cognitive impairment in a mixed murine model of Alzheimer's disease and type 2 diabetes

MJ Carranza-Naval, A Del Marco… - Frontiers in aging …, 2021 - frontiersin.org
Alzheimer's disease is the most common form of dementia, and epidemiological studies
support that type 2 diabetes (T2D) is a major contributor. The relationship between both …

[HTML][HTML] HMGB1 signaling pathway in diabetes-related dementia: Blood-brain barrier breakdown, brain insulin resistance, and Aβ accumulation

J Jeong, DH Lee, J Song - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Diabetes contributes to the onset of various diseases, including cancer and cardiovascular
and neurodegenerative diseases. Recent studies have highlighted the similarities and …

Acceleration of brain atrophy and progression from normal cognition to mild cognitive impairment

Y Uchida, K Nishimaki, A Soldan… - JAMA Network …, 2024 - jamanetwork.com
Importance It remains unclear which risk factors accelerate brain atrophy along with a
progression from normal cognition to mild cognitive impairment (MCI). Objective To examine …