A journey from structure to function of bacterial lipopolysaccharides

F Di Lorenzo, KA Duda, R Lanzetta, A Silipo… - Chemical …, 2021 - ACS Publications
Lipopolysaccharide (LPS) is a crucial constituent of the outer membrane of most Gram-
negative bacteria, playing a fundamental role in the protection of bacteria from …

Lipopolysaccharide and the gut microbiota: considering structural variation

AE Mohr, M Crawford, P Jasbi, S Fessler… - FEBS …, 2022 - Wiley Online Library
Systemic inflammation is associated with chronic disease and is purported to be a main
pathogenic mechanism underlying metabolic conditions. Microbes harbored in the host …

Heterogeneity of lipopolysaccharide as source of variability in bioassays and LPS-binding proteins as remedy

AC Fux, C Casonato Melo, S Michelini… - International Journal of …, 2023 - mdpi.com
Lipopolysaccharide (LPS), also referred to as endotoxin, is the major component of Gram-
negative bacteria's outer cell wall. It is one of the main types of pathogen-associated …

Triggerable prodrug nanocoating enables on-demand activation of microbial and small-molecular therapeutics for combination treatment

X Kuang, Y Liu, H Luo, Q Li, F Wu… - Journal of the American …, 2023 - ACS Publications
The synergy of living microbial and small-molecular therapeutics has been widely explored
for treating a variety of diseases, while current combination strategies often suffer from low …

Chemical synthesis of glycans up to a 128-mer relevant to the O-antigen of Bacteroides vulgatus

Q Zhu, Z Shen, F Chiodo, S Nicolardi… - Nature …, 2020 - nature.com
Glycans are involved in various life processes and represent critical targets of biomedical
developments. Nevertheless, the accessibility to long glycans with precise structures …

Bacteroides vulgatus ameliorates lipid metabolic disorders and modulates gut microbial composition in hyperlipidemic rats

M Xu, R Lan, L Qiao, X Lin, D Hu, S Zhang… - Microbiology …, 2023 - Am Soc Microbiol
Hyperlipidemia is a risk factor and key indicator for cardiovascular diseases, and the gut
microbiota is highly associated with hyperlipidemia. Bacteroides vulgatus is a prevalent …

The lipooligosaccharide of the gut symbiont Akkermansia muciniphila exhibits a remarkable structure and TLR signaling capacity

P Garcia-Vello, HLP Tytgat, J Elzinga… - Nature …, 2024 - nature.com
The cell-envelope of Gram-negative bacteria contains endotoxic lipopolysaccharides (LPS)
that are recognized by the innate immune system via Toll-Like Receptors (TLRs). The …

Gut microbial signatures for glycemic responses of GLP-1 receptor agonists in type 2 diabetic patients: a pilot study

CY Tsai, HC Lu, YH Chou, PY Liu, HY Chen… - Frontiers in …, 2022 - frontiersin.org
Backgrounds Glucagon-like peptide-1 receptor agonist (GLP-1 RA) is probably one of more
effective antidiabetic agents in treatment of type 2 diabetes mellitus (T2D). However, the …

Recent advances in gut microbiota-associated natural products: structures, bioactivities, and mechanisms

H Dai, J Han, T Wang, WB Yin, Y Chen, H Liu - Natural product reports, 2023 - pubs.rsc.org
Covering: 2014 to June 2022 The gut microbiota has attracted increasing attention from
researchers due to its critical role in regulating human physiology and pathophysiology …

Lipopolysaccharide lipid A: A promising molecule for new immunity-based therapies and antibiotics

P Garcia-Vello, F Di Lorenzo, D Zucchetta… - Pharmacology & …, 2022 - Elsevier
Lipopolysaccharides (LPS) are the main components of the external leaflet of the Gram-
negative outer membrane and consist of three different moieties: lipid A, core …