Natural products and their analogues acting against Mycobacterium tuberculosis: A recent update

G Kumar - Drug Development Research, 2023 - Wiley Online Library
Tuberculosis (TB) remains one of the deadliest infectious diseases caused by
Mycobacterium tuberculosis (M. tb). It is responsible for significant causes of mortality and …

In silico drug design strategies for discovering novel tuberculosis therapeutics

CSC Canales, AR Pavan, JL Dos Santos… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Tuberculosis remains a significant concern in global public health due to its
intricate biology and propensity for developing antibiotic resistance. Discovering new drugs …

Molecular insights into the inhibition mechanism of harringtonine against essential proteins associated with SARS-CoV-2 entry

Z Yang, X Fu, Y Zhao, X Li, J Long, L Zhang - International Journal of …, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has recently posed a
serious threat to global public health. Harringtonine (HT), as a small-molecule antagonist …

Chalcones as anti-infective agents for effective management of tuberculosis

S Mishra, P Jana - Polycyclic Aromatic Compounds, 2024 - Taylor & Francis
After the pandemic COVID-19, global health agencies remind us that tuberculosis is the
deadliest infectious disease worldwide. As per WHO reports, approximately ten million …

Design, Synthesis, and in vitro Biological Evaluation of ROS‐Generating Phenanthridin‐trione‐Epoxide Conjugates as Agents against Mycobacterium tuberculosis

R Mamgain, S Swami, D Sarkar… - ChemistrySelect, 2023 - Wiley Online Library
Tuberculosis (TB) is one of the devasting infectious diseases and continues to spread
among people despite having several specific drugs. Total eradication of TB is one of the …

Regio-and chemoselective synthesis of polyaryl flavones by combination of CO/CH activation and Suzuki-Miyaura cross coupling reactions

E Schaeffer, NC de Oliveira, Y Pestana… - Journal of Molecular …, 2024 - Elsevier
The first regioselective ruthenium-catalyzed arylation of flavone-derived compounds is
reported. Exploring the molecular structure-reactivity different 5-, 5, 8-, 5, 7-, 5, 6-and 5, 7, 8 …

First synthetic report and antioxidant potential of natural product (±)-5, 7-dihydroxy-8-methyl-3-(2', 4'-dihydroxybenzyl) chroman-4-one from Chinese medicine Gan Luo …

NV Puranik, G Mishra, S Gulawani… - Natural Product …, 2022 - Taylor & Francis
The first synthetic route of naturally occurring (±)-5, 7-dihydroxy-8-methyl-3-(2', 4'-
dihydroxybenzyl) chroman-4-one (1) from Gan Luo Xin pill was successfully accomplished …

From biomass to natural flavonoids: Studies for total synthesis of Podocarflavone A

G dos Santos Ramos, MB dos Santos, E Schaeffer… - schenautomacao.com.br
Natural products are secondary metabolites produced by plants for various functions. 1
Flavonoids, a class of these metabolites, are polyphenolic compounds vital for plant …