The STUB1 gene (STIP1 homology and U-box-containing protein 1), located at 16q13. 3,
encodes the CHIP (carboxyl terminus of Hsc70-interacting protein), an essential E3 ligase …

Gliomas constitute the most frequent tumors of the brain. High-grade gliomas are
characterized by a poor prognosis caused by a set of attributes making treatment difficult …

The tumor suppressor, PTEN is key to the regulation of diverse cellular processes, making it
a prime candidate to be tightly regulated. The PTEN level is controlled in a major way by E3 …

Enhancer of zeste homolog 2 (EZH 2) has been characterized as a critical oncogene and a
promising drug target in human malignant tumors. The current EZH 2 inhibitors strongly …

Angiogenesis, the formation of new blood vessels from the pre-existing vasculature is
essential for embryonic development and tissue homeostasis. It also plays critical roles in …

The primary cilium emanates from the cell surface of growth-arrested cells and plays a
central role in vertebrate development and tissue homeostasis. The mechanisms that control …

Malignant glioma is the most common type of primary brain tumor in adults, characterized by
rapid tumor growth and infiltration of tumor cells throughout the brain. Alterations in the …

Carboxyl terminus of heat shock protein 70-interacting protein (CHIP) is an E3 ubiquitin
ligase that is involved in protein quality control and mediates several tumor-related proteins …

Cardiac myocytes are terminally differentiated cells and possess extremely limited
regenerative capacity; therefore, preservation of mature cardiac myocytes throughout the …

Heat shock proteins (HSPs) are a family of molecular chaperones that regulate essential
protein refolding and triage decisions to maintain protein homeostasis. Numerous co …