Drug resistance and tolerance in fungi
J Berman, DJ Krysan - Nature Reviews Microbiology, 2020 - nature.com
Systemic fungal infections pose a serious clinical problem. Treatment options are limited,
and antifungal drug resistance is increasing. In addition, a substantial proportion of patients …
and antifungal drug resistance is increasing. In addition, a substantial proportion of patients …
Fungal Lanosterol 14α-demethylase: A target for next-generation antifungal design
The cytochrome P450 enzyme lanosterol 14α-demethylase (LDM) is the target of the azole
antifungals used widely in medicine and agriculture as prophylaxis or treatments of …
antifungals used widely in medicine and agriculture as prophylaxis or treatments of …
[HTML][HTML] Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia
Tolerance to antifungal drug concentrations above the minimal inhibitory concentration
(MIC) is rarely quantified, and current clinical recommendations suggest it should be …
(MIC) is rarely quantified, and current clinical recommendations suggest it should be …
Mitochondria-specific aggregation-induced emission luminogens for selective photodynamic killing of fungi and efficacious treatment of keratitis
The development of effective antifungal agents remains a big challenge in view of the close
evolutionary relationship between mammalian cells and fungi. Moreover, rapid mutations of …
evolutionary relationship between mammalian cells and fungi. Moreover, rapid mutations of …
Bacterial-derived exopolysaccharides enhance antifungal drug tolerance in a cross-kingdom oral biofilm
Fungal–bacterial interactions generate unique biofilms that cause many infections in
humans. Candida albicans interact with Streptococcus mutans in dental biofilms associated …
humans. Candida albicans interact with Streptococcus mutans in dental biofilms associated …
Fluorescent 7-azaindole N-linked 1, 2, 3-triazole: synthesis and study of antimicrobial, molecular docking, ADME and DFT properties
Two libraries of biologically essential and fluorescent 7-azaindole N-linked benzyl 1, 2, 3-
triazole (4a–4i) and 7-azaindole N-linked phenyl 1, 2, 3-triazole (4j–4q) hybrids have been …
triazole (4a–4i) and 7-azaindole N-linked phenyl 1, 2, 3-triazole (4j–4q) hybrids have been …
Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles
Azole antifungals inhibit the biosynthesis of ergosterol, the fungal equivalent of cholesterol
in mammalian cells. Here we report an investigation of the activity of coumarin-substituted …
in mammalian cells. Here we report an investigation of the activity of coumarin-substituted …
An atypical ABC transporter is involved in antifungal resistance and host interactions in the pathogenic fungus Cryptococcus neoformans
CJ Winski, Y Qian, S Mobashery, FH Santiago-Tirado - Mbio, 2022 - Am Soc Microbiol
ABSTRACT ATP-binding cassette (ABC) transporters represent one of the largest protein
superfamilies. Functionally diverse, ABC transporters have been implicated in many aspects …
superfamilies. Functionally diverse, ABC transporters have been implicated in many aspects …
[HTML][HTML] Drug repurposing strategy II: from approved drugs to agri-fungicide leads
JX An, Y Ma, WB Zhao, YM Hu, YR Wang… - The Journal of …, 2023 - nature.com
Epidemic diseases of crops caused by fungi deeply affected the course of human history
and processed a major restriction on social and economic development. However, with the …
and processed a major restriction on social and economic development. However, with the …
Guanylated hyperbranched polylysines with high in vitro and in vivo antifungal activity
X Liu, Y Yang, M Han, J Guo, H Liu… - Advanced …, 2022 - Wiley Online Library
With the rapid growth of fungal infections and the emergence of multi‐drug resistant (MDR)
fungal strains, new antifungals with novel mechanisms are a pressing need to tackle this …
fungal strains, new antifungals with novel mechanisms are a pressing need to tackle this …