In addition to genetic information, environmental factors play an important role in the
structure and function of nervous system and the occurrence and development of some …

Abstract Environmental enrichment (“EE”) is expected to alleviate the negative effects of
stress on cognitive performance. However, there are complexities associated with …

Addiction is a chronic relapsing disorder with devastating personal, societal, and economic
consequences. In humans, early‐life adversity (ELA) such as trauma, neglect, and resource …

Introduction Early social isolation (ESI) disrupts neurodevelopmental processes, potentially
leading to long-lasting emotional and cognitive changes in adulthood. Communal nesting …

The term 'perinatal environment'refers to the period surrounding birth, which plays a crucial
role in brain development. It has been suggested that dynamic communication between the …

In humans, exposure to early life stress (ELS) is an established risk factor for the
development of substance use disorders (SUDs) during later life. Similarly, rodents exposed …

Early-life stress disrupts central nervous system development and increases the risk of
neuropsychiatric disorder in offspring based on rodent studies. Maternal sleep deprivation …

Opioid use disorder (OUD) rarely presents as a unitary psychiatric condition, and the
comorbid symptoms likely depend upon the diverse risk factors and mechanisms by which …

An animal model of voluntary oral morphine consumption would allow for a pre-clinical
evaluation of new treatments aimed at reducing opioid intake in humans. However, the main …

The present study investigates the possible therapeutic effects of human mesenchymal stem
cell-derived secretome on morphine dependence and relapse. This was studied in a new …