Epidemiological surveys indicate that the incidence of inflammatory bowel disease (IBD) is
increasing rapidly with the continuous growth of the economy. A large number of studies …

Variability in disease presentation, progression and treatment response has been a central
challenge in medicine. Although variability in host factors and genetics are important, it has …

Background Well-balanced interactions between gut microbiota and the immune system are
essential to prevent chronic intestinal inflammation, as observed in inflammatory bowel …

Bacterial activation of T helper 17 (Th17) cells exacerbates mouse models of autoimmunity,
but how human-associated bacteria impact Th17-driven disease remains elusive. We show …

Fecal microbiota transplantation (FMT) has been successfully applied to treat recurrent
Clostridium difficile infection in humans, but a precise method to measure which bacterial …

Background Crohn's disease (CD) is a chronic inflammatory disorder characterized by
intestinal immune dysfunction. Multiple factors, including gut dysbiosis, are involved in the …

Inflammatory bowel disease (IBD) is a complex multifactorial chronic inflammatory disease,
that includes Crohn's disease (CD) and ulcerative colitis (UC), having progressively …

Gut microbiota is a potent biological modulator of many physiological and pathological
states. The renin-angiotensin system (RAS), including the local gastrointestinal RAS (GI …

The potential of commensal bacteria to modulate host immunity remains largely
uncharacterized, largely due to the vast number of strains that comprise the human gut …

Autoimmune diseases have long been known to share a common pathogenesis involving a
dysregulated immune system with a failure to recognize self from non-self-antigens. This …