ADP-ribosylation (ADPRylation) is a post-translational modification of proteins catalyzed by
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …

Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease
(PD), are characterized by progressive memory loss and motor impairment. Aging is a major …

ADP-ribosylation is an intricate and versatile posttranslational modification involved in the
regulation of a vast variety of cellular processes in all kingdoms of life. Its complexity derives …

Protein ADP-ribosylation is essential for the regulation of several cellular pathways,
enabling dynamic responses to diverse pathophysiological conditions. It is modulated …

ADP-ribosylation (ADPRylation) is a posttranslational modification of proteins discovered
nearly six decades ago, but many important questions remain regarding its molecular …

The functionality of DNA, RNA and proteins is altered dynamically in response to
physiological and pathological cues, partly achieved by their modification. While the …

Poly (ADP-ribose) polymerases (PARP) 1-3 are well-known multi-domain enzymes,
catalysing the covalent modification of proteins, DNA, and themselves. They attach mono-or …

Abstract Poly (ADP‐ribose) polymerases (PARPs) are abundant nuclear proteins that
synthesize ADP ribose polymers (pADPr) and catalyze the addition of (p) ADPr to target …

The nucleolus has been known for a long time to fulfill crucial functions in ribosome
biogenesis, of which cancer cells can become addicted to in order to produce sufficient …

Replication of viruses requires interaction with host cell factors and repression of innate
immunity. Recent findings suggest that a subset of intracellular mono-ADP-ribosylating …