Inflammatory chemokines in atherosclerosis

S Gencer, BR Evans, EPC van der Vorst, Y Döring… - Cells, 2021 - mdpi.com
Atherosclerosis is a long-term, chronic inflammatory disease of the vessel wall leading to the
formation of occlusive or rupture-prone lesions in large arteries. Complications of …

Innate immune receptors in platelets and platelet-leukocyte interactions

PRB Dib, AC Quirino-Teixeira, LB Merij… - Journal of Leucocyte …, 2020 - academic.oup.com
Platelets are chief cells in hemostasis. Apart from their hemostatic roles, platelets are major
inflammatory effector cells that can influence both innate and adaptive immune responses …

The role of CXCL16 in the pathogenesis of cancer and other diseases

J Korbecki, K Bajdak-Rusinek, P Kupnicka… - International journal of …, 2021 - mdpi.com
CXCL16 is a chemotactic cytokine belonging to the α-chemokine subfamily. It plays a
significant role in the progression of cancer, as well as the course of atherosclerosis, renal …

Current concepts and novel targets for antiplatelet therapy

M Gawaz, T Geisler, O Borst - Nature Reviews Cardiology, 2023 - nature.com
Platelets have a crucial role in haemostasis and atherothrombosis. Pharmacological control
of platelet hyper-reactivity has become a cornerstone in the prevention of thrombo …

[HTML][HTML] Chemokines and eicosanoids fuel the hyperinflammation within the lungs of patients with severe COVID-19

Y Zaid, E Dore, I Dubuc, AS Archambault… - Journal of Allergy and …, 2021 - Elsevier
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can
lead to a variety of clinical outcomes, ranging from the absence of symptoms to severe acute …

Platelets mediate oxidized low-density lipoprotein–induced monocyte extravasation and foam cell formation

S Badrnya, WC Schrottmaier, JB Kral… - … , and vascular biology, 2014 - Am Heart Assoc
Objective—A growing body of evidence indicates that platelets contribute to the onset and
progression of atherosclerosis by modulating immune responses. We aimed to elucidate the …

Chemokines, molecular drivers of thromboinflammation and immunothrombosis

J Leberzammer, P von Hundelshausen - Frontiers in Immunology, 2023 - frontiersin.org
Blood clotting is a finely regulated process that is essential for hemostasis. However, when
dysregulated or spontaneous, it promotes thrombotic disorders. The fact that these are …

Platelets and their chemokines in atherosclerosis—clinical applications

P von Hundelshausen, MMN Schmitt - Frontiers in physiology, 2014 - frontiersin.org
The concept of platelets as important players in the process of atherogenesis has become
increasingly accepted due to accumulating experimental and clinical evidence. Despite the …

LipidCreator workbench to probe the lipidomic landscape

B Peng, D Kopczynski, BS Pratt, CS Ejsing… - Nature …, 2020 - nature.com
Mass spectrometry (MS)-based targeted lipidomics enables the robust quantification of
selected lipids under various biological conditions but comprehensive software tools to …

The role of platelet P2Y12 receptors in inflammation

WAE Parker, RF Storey - British Journal of Pharmacology, 2024 - Wiley Online Library
Inflammation is a complex pathophysiological process underlying many clinical conditions.
Platelets contribute to the thrombo‐inflammatory response. Platelet P2Y12 receptors amplify …