Salvia species are important medicinal and culinary plants, and they have been the subject
of numerous chemical and biological studies. The bioactive triterpenoids of Salvia species …

Salvia divinorum is a perennial sage native to Oaxaca, Mexico, that has been used
traditionally in divination rituals and as a treatment for the “semimagical” disease panzón de …

The κ-opioid receptor (KOR) represents a highly desirable therapeutic target for treating not
only pain but also addiction and affective disorders. However, the development of KOR …

Salvia divinorum, whose main active ingredient is the neoclerodane diterpene Salvinorin A,
is a hallucinogenic plant in the mint family that has been used in traditional spiritual …

Structural modification of salvinorin A, the active component of Salvia divinorum, has
resulted in the synthesis of novel neoclerodane diterpenes with opioid receptor affinity and …

Salvinorin A, a neoclerodane diterpene, is the most potent naturally occurring hallucinogen
known and rivals the synthetic hallucinogen lysergic acid diethylamide in potency. Recently …

Plants provide the food, shelter, medicines, and biomass that underlie sustainable life. One
of the earliest and often overlooked uses of plants is the production of smoke, dating to the …

Rationale The hallucinatory effect and potential abuse of salvinorin A, the major ingredient
of Salvia divinorum, has not been documented in animals. Objective The effects of salvinorin …

Opioids such as morphine, codeine, and oxycodone are extracts or analogs isolated from a
single source: the opium poppy. For a long time, it was believed to be nature's only source of …

Because psychoactive plants exert profound effects on human perception, emotion, and
cognition, discovering the molecular mechanisms responsible for psychoactive plant actions …