Nitric oxide (NO) is an important signaling molecule that is involved in a wide range of
physiological and pathological events in biology. Metal coordination chemistry, especially …

The discovery of soluble GC (sGC) stimulators and sGC activators provided valuable tools to
elucidate NO–sGC signalling and opened novel pharmacological opportunities for …

A density-modification procedure for improving maps from single-particle electron cryogenic
microscopy (cryo-EM) is presented. The theoretical basis of the method is identical to that of …

Cyclic guanosine monophosphate (cGMP) is a unique second messenger molecule formed
in different cell types and tissues. cGMP targets a variety of downstream effector molecules …

Soluble guanylate cyclase (sGC) is the receptor for nitric oxide (NO) in human. It is an
important validated drug target for cardiovascular diseases. sGC can be pharmacologically …

Enzyme function requires conformational changes to achieve substrate binding, domain
rearrangements, and interactions with partner proteins, but these movements are difficult to …

Nitric oxide (NO) is one of the most ancient and versatile signal molecules across all
domains of life. NO signaling might also play an essential role in the origin of animal …

Introduction Colorectal cancer (CRC) is a devastating disease that affects millions of people
worldwide. Recent research has highlighted the crucial role of the guanylate cyclase-C (GC …

Nitric oxide (NO) is a ubiquitous gaseous messenger, but we know little about its early
evolution. Here, we analyzed NO synthases (NOS) in four different species of placozoans …

The cyclic guanosine monophosphate (cGMP) signaling system is one of the most
prominent regulators of a variety of physiological and pathophysiological processes in many …