Role of elastic fiber degradation in disease pathogenesis

G Halsey, D Sinha, S Dhital, X Wang… - Biochimica et Biophysica …, 2023 - Elsevier
Elastin is a crucial extracellular matrix protein that provides structural integrity to tissues.
Crosslinked elastin and associated microfibrils, named elastic fiber, contribute to …

Pseudoexfoliation syndrome: The critical role of the extracellular matrix in pathogenesis and treatment

S Mastronikolis, M Pagkalou, G Baroutas… - Iubmb …, 2022 - Wiley Online Library
Pseudoexfoliation syndrome (PEXS) is an age‐related condition manifesting mainly in
ocular tissues. PEXS is manifested through excess aggregation of fibrillary extracellular …

[HTML][HTML] Automated AI labeling of optic nerve head enables insights into cross-ancestry glaucoma risk and genetic discovery in> 280,000 images from UKB and CLSA

X Han, K Steven, A Qassim, HN Marshall… - The American Journal of …, 2021 - cell.com
Cupping of the optic nerve head, a highly heritable trait, is a hallmark of glaucomatous optic
neuropathy. Two key parameters are vertical cup-to-disc ratio (VCDR) and vertical disc …

Metabolomics reveals differences in aqueous humor composition in patients with and without pseudoexfoliation syndrome

DA Dmuchowska, K Pietrowska, P Krasnicki… - Frontiers in Molecular …, 2021 - frontiersin.org
Pseudoexfoliation syndrome (XFS) is stress-or inflammation-induced elastosis accompanied
by excessive production of microfibrils and their deposition in the anterior segment of the …

Abdominal aortic aneurysm and exfoliation syndrome: A literature review comparing single site findings

A Patil, M Conley, C Paulson, C Pompoco… - Acta …, 2023 - Wiley Online Library
Several studies have suggested a possible relationship between exfoliation syndrome (XFS)
and abdominal aortic aneurysm (AAA). A systematic literature review was undertaken to …

Effect of long-term chronic hyperhomocysteinemia on retinal structure and function in the cystathionine-β-synthase mutant mouse

H Xiao, J Wang, SR Barwick, Y Yoon… - Experimental eye …, 2022 - Elsevier
Elevated levels of the excitatory amino acid homocysteine (Hcy) have been implicated in
retinal diseases in humans including glaucoma and macular degeneration. It is not clear …

Increased desmosine in the lens capsules is associated with augmented elastin turnover in pseudoexfoliation syndrome

M Rebecca, K Sripriya, M Bharathselvi… - Experimental Eye …, 2022 - Elsevier
Pseudoexfoliation syndrome (PXF) is an idiopathic disease with a high prevalence rate. The
elastosis disorder is contributed by genetic and non-genetic factors. Elastin dysregulation …

Relationship between homocysteine levels, anterior chamber depth, and pseudoexfoliation glaucoma in patients with pseudoexfoliation

H Koc, F Kaya - International Ophthalmology, 2020 - Springer
Purpose This study investigates the relationship between plasma homocysteine levels,
anterior chamber depth (ACD), and pseudoexfoliation glaucoma (PEXG) in patients with …

[HTML][HTML] The association between ethnicity, environmental and lifestyle factors and chronic disease in the development of pseudoexfoliation syndrome

SA Arif, MI Khan, F Nauman, MA Arif - Pakistan Journal of Medical …, 2021 - ncbi.nlm.nih.gov
Objectives: To determine the association between ethnicity, environmental factors, lifestyle
factors, chronic diseases and pseudoexfoliation syndrome (PEX). Methods: A case control …

A comprehensive enhanced depth imaging spectral-domain optical coherence tomography analysis of pseudoexfoliation spectrum from non-glaucomatous to …

M Hepokur, CY Elgin, M Gunes, F Sali… - International …, 2022 - Springer
Purpose To compare the correlations between lamina cribrosa (LC) and related structures
with Bruch's membrane opening-minimum rim width (BMO-MRW) and retinal nerve fiber …