The tRNA identity landscape for aminoacylation and beyond
R Giegé, G Eriani - Nucleic Acids Research, 2023 - academic.oup.com
Abstract tRNAs are key partners in ribosome-dependent protein synthesis. This process is
highly dependent on the fidelity of tRNA aminoacylation by aminoacyl-tRNA synthetases …
highly dependent on the fidelity of tRNA aminoacylation by aminoacyl-tRNA synthetases …
Modifications of the human tRNA anticodon loop and their associations with genetic diseases
JB Zhou, ED Wang, XL Zhou - Cellular and Molecular Life Sciences, 2021 - Springer
Transfer RNAs (tRNAs) harbor the most diverse posttranscriptional modifications. Among
such modifications, those in the anticodon loop, either on nucleosides or base groups …
such modifications, those in the anticodon loop, either on nucleosides or base groups …
Mammalian mitochondrial translation infidelity leads to oxidative stress–induced cell cycle arrest and cardiomyopathy
WQ Zheng, JH Zhang, ZH Li, X Liu… - Proceedings of the …, 2023 - National Acad Sciences
Proofreading (editing) of mischarged tRNAs by cytoplasmic aminoacyl-tRNA synthetases
(aaRSs), whose impairment causes neurodegeneration and cardiac diseases, is of high …
(aaRSs), whose impairment causes neurodegeneration and cardiac diseases, is of high …
RNA granule-clustered mitochondrial aminoacyl-tRNA synthetases form multiple complexes with the potential to fine-tune tRNA aminoacylation
GX Peng, XL Mao, Y Cao, SY Yao, QR Li… - Nucleic Acids …, 2022 - academic.oup.com
Mitochondrial RNA metabolism is suggested to occur in identified compartmentalized foci, ie
mitochondrial RNA granules (MRGs). Mitochondrial aminoacyl-tRNA synthetases (mito …
mitochondrial RNA granules (MRGs). Mitochondrial aminoacyl-tRNA synthetases (mito …
Molecular basis for human mitochondrial tRNA m3C modification by alternatively spliced METTL8
MH Huang, GX Peng, XL Mao, JT Wang… - Nucleic acids …, 2022 - academic.oup.com
METTL8 has recently been identified as the methyltransferase catalyzing 3-methylcytidine
biogenesis at position 32 (m3C32) of mitochondrial tRNAs. METTL8 also potentially …
biogenesis at position 32 (m3C32) of mitochondrial tRNAs. METTL8 also potentially …
Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA
B Kuhle, M Hirschi, LK Doerfel, GC Lander… - Nature …, 2022 - nature.com
Human mitochondrial gene expression relies on the specific recognition and aminoacylation
of mitochondrial tRNAs (mtRNAs) by nuclear-encoded mitochondrial aminoacyl-tRNA …
of mitochondrial tRNAs (mtRNAs) by nuclear-encoded mitochondrial aminoacyl-tRNA …
Mutually exclusive substrate selection strategy by human m3C RNA transferases METTL2A and METTL6
XL Mao, ZH Li, MH Huang, JT Wang… - Nucleic acids …, 2021 - academic.oup.com
Abstract tRNAs harbor the most diverse posttranscriptional modifications. The 3-
methylcytidine (m3C) is widely distributed at position C32 (m3C32) of eukaryotic tRNAThr …
methylcytidine (m3C) is widely distributed at position C32 (m3C32) of eukaryotic tRNAThr …
Structural basis for a degenerate tRNA identity code and the evolution of bimodal specificity in human mitochondrial tRNA recognition
B Kuhle, M Hirschi, LK Doerfel, GC Lander… - Nature …, 2023 - nature.com
Animal mitochondrial gene expression relies on specific interactions between nuclear-
encoded aminoacyl-tRNA synthetases and mitochondria-encoded tRNAs. Their evolution …
encoded aminoacyl-tRNA synthetases and mitochondria-encoded tRNAs. Their evolution …
[HTML][HTML] Mitochondrial RNA m3C methyltransferase METTL8 relies on an isoform-specific N-terminal extension and modifies multiple heterogenous tRNAs
MH Huang, JT Wang, JH Zhang, XL Mao, GX Peng… - Science Bulletin, 2023 - Elsevier
Abstract Methyltransferase-like 8 (METTL8) encodes a mitochondria-localized METTL8-Iso1
and a nucleolus-distributed METTL8-Iso4 isoform, which differ only in their N-terminal …
and a nucleolus-distributed METTL8-Iso4 isoform, which differ only in their N-terminal …
Commonality and diversity in tRNA substrate recognition in t6A biogenesis by eukaryotic KEOPSs
Abstract N 6-Threonylcarbamoyladenosine (t6A) is a universal and pivotal tRNA
modification. KEOPS in eukaryotes participates in its biogenesis, whose mutations are …
modification. KEOPS in eukaryotes participates in its biogenesis, whose mutations are …