The 3 major types of innate and adaptive cell-mediated effector immunity

F Annunziato, C Romagnani, S Romagnani - Journal of Allergy and Clinical …, 2015 - Elsevier
The immune system has tailored its effector functions to optimally respond to distinct species
of microbes. Based on emerging knowledge on the different effector T-cell and innate …

Effector functions of CD4+ T cells at the site of local autoimmune inflammation—lessons from rheumatoid arthritis

K Chemin, C Gerstner, V Malmström - Frontiers in immunology, 2019 - frontiersin.org
Infiltration of memory CD4+ T cells in synovial joints of Rheumatoid Arthritis (RA) patients
has been reported since decades. Moreover, several genome wide association studies …

Observation of Bose-Einstein condensation in a dilute atomic vapor

MH Anderson, JR Ensher, MR Matthews, CE Wieman… - science, 1995 - science.org
A Bose-Einstein condensate was produced in a vapor of rubidium-87 atoms that was
confined by magnetic fields and evaporatively cooled. The condensate fraction first …

Of mice and not men: differences between mouse and human immunology

J Mestas, CCW Hughes - The Journal of Immunology, 2004 - journals.aai.org
Mice are the experimental tool of choice for the majority of immunologists and the study of
their immune responses has yielded tremendous insight into the workings of the human …

Allergic rhinitis and its impact on asthma

J Bousquet, P Van Cauwenberge… - Journal of allergy and …, 2001 - jacionline.org
Allergic rhinitis is clinically defined as a symptomatic disorder of the nose induced by an IgE-
mediated inflammation after allergen exposure of the membranes lining the nose. Symptoms …

The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells

W Zheng, RA Flavell - Cell, 1997 - cell.com
CD4 T cells potentiate the inflammatory or humoral immune response through the action of
Th1 and Th2 cells, respectively. The molecular basis of the differentiation of these cells from …

Is IgE or eosinophils the key player in allergic asthma pathogenesis? Are we asking the right question?

A Matucci, A Vultaggio, E Maggi, I Kasujee - Respiratory research, 2018 - Springer
Bronchial asthma (BA) is a chronic inflammatory disease with a marked heterogeneity in
pathophysiology and etiology. The heterogeneity of BA may be related to the inducing …

T-cell subsets (Th1 versus Th2)

S Romagnani - Annals of allergy, asthma & immunology, 2000 - Elsevier
LEARNING OBJECTIVE: To understand the current status of knowledge in the basic field of
polarized specific immune responses mediated by CD4+ T helper (Th) lymphocytes, based …

Allergy and allergic diseases

AB Kay - New England Journal of Medicine, 2001 - Mass Medical Soc
Allergic rhinitis, asthma, and atopic eczema are among the commonest causes of chronic ill
health. These diseases are increasing in prevalence, and they add considerably to the …

Lymphocyte responses and cytokines

WE Paul, RA Seder - Cell, 1994 - Elsevier
T lymphocytes are the central regulatory cells of the immune system. Much of their function is
mediated by a set of small proteins whose expression, secretion, or both is induced as a …