Greenness assessment of UPLC/MS/MS method for determination of two antihypertensive agents and their harmful impurities with ADME/TOX profile study

HM Nagieb, NS Abdelwahab, MM Abdelrahman… - Scientific Reports, 2023 - nature.com
Hypertension is described by the world health organization (WHO) as a serious medical
problem that significantly affects the heart, brain and kidneys. It is a major cause of …

Separation methods for captopril in pharmaceuticals and biological fluids

FR Mansour, ND Danielson - Journal of separation science, 2012 - Wiley Online Library
Captopril (CAP) is an orally active angiotensin‐converting enzyme (ACE) inhibitor and has
been widely used for management of hypertension and congestive heart failure. CAP lacks …

Simultaneous determination of captopril and hydrochlorothiazide on boron-doped diamond electrode by batch injection analysis with multiple pulse amperometric …

DT Gimenes, MC Marra, JM de Freitas… - Sensors and Actuators B …, 2015 - Elsevier
This work describes a new, simple, and fast electrochemical method for simultaneous
determination of captopril (CAP) and hydrochlorothiazide (HCT) using a boron-doped …

The use of experimental design in the development of an HPLC–ECD method for the analysis of captopril

SM Khamanga, RB Walker - Talanta, 2011 - Elsevier
An accurate, sensitive and specific high performance liquid chromatography–
electrochemical detection (HPLC–ECD) method that was developed and validated for …

Development and validation of eco-friendly micellar organic solvent-free HPLC method for the simultaneous determination of some antihypertensive combinations

EA Bahgat, H Saleh, A Reda, MG Fawzy - Microchemical Journal, 2022 - Elsevier
To minimize the environmental impacts of using organic solvent without affecting the
chromatographic performance, alternatives had to be utilized to decrease such pollution …

[PDF][PDF] Captopril and Hydrochlorothiazide: Insights on Pharmacology and Analytical Chemistry Profile

MM Sebaiy, KM Hegazy, AM Ebrahim… - Journal of Chemistry …, 2022 - researchgate.net
Many categories of drugs are used today for hypertension such as captopril which belongs
to ACE inhibitors family and hydrochlorothiazide which consider a diuretic drug. In this …

A simple and rapid high-performance liquid chromatographic method for the determination of bisoprolol fumarate and hydrochlorothiazide in a tablet dosage form

S Shaikh, OA Thusleem, MS Muneera, J Akmal… - … of pharmaceutical and …, 2008 - Elsevier
A simple and precise high performance liquid chromatographic method has been developed
and validated for the simultaneous determination of bisoprolol fumarate (BF), and …

Cyclodextrin-and solvent-modified micellar electrokinetic chromatography for the determination of captopril, hydrochlorothiazide and their impurities: a quality by …

B Pasquini, S Orlandini, C Caprini, M Del Bubba… - Talanta, 2016 - Elsevier
A fast and selective capillary electrophoresis method has been developed for the
simultaneous determination of the antihypertensive drugs captopril and hydrochlorothiazide …

Simultaneous determination of captopril and hydrochlorothiazide by using a carbon ionic liquid electrode modified with copper hydroxide nanoparticles

G Absalan, M Akhond, R Karimi, AM Ramezani - Microchimica Acta, 2018 - Springer
A carbon electrode modified with the ionic liquid octylpyridinium hexafluorophosphate and
copper hydroxide nanoparticles was employed in an electrochemical assay for …

[PDF][PDF] Validation of an analytical procedure for simultaneous determination of hydrochlorothiazide, lisinopril, and their impurities

D Ivanovic, M Medenica, B Jancic… - Acta …, 2007 - researchgate.net
The main objective of the work discussed in this paper was evaluation of a chromatographic
method for simultaneous determination of hydrochlorothiazide (HCTZ), lisinopril (L), and …