The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review

J Zeng, T Bao, K Yang, X Zhu, S Wang… - Frontiers in …, 2023 - frontiersin.org
Ischemic stroke (IS) is one of the most fatal diseases. Neuroimmunity, inflammation, and
oxidative stress play important roles in various complex mechanisms of IS. In particular, the …

Fisetin, a potent anticancer flavonol exhibiting cytotoxic activity against neoplastic malignant cells and cancerous conditions: a scoping, comprehensive review

R Kubina, K Krzykawski, A Kabała-Dzik, RD Wojtyczka… - Nutrients, 2022 - mdpi.com
Diet plays a crucial role in homeostasis maintenance. Plants and spices containing
flavonoids have been widely used in traditional medicine for thousands of years. Flavonols …

Engineered production of bioactive polyphenolic O-glycosides

J Ren, CD Barton, J Zhan - Biotechnology Advances, 2023 - Elsevier
Polyphenolic compounds (such as quercetin and resveratrol) possess potential medicinal
values due to their various bioactivities, but poor water solubility hinders their health benefits …

Fisetin in cancer: attributes, developmental aspects, and nanotherapeutics

RM Kumar, H Kumar, T Bhatt, R Jain, K Panchal… - Pharmaceuticals, 2023 - mdpi.com
Cancer is one of the major causes of mortality, globally. Cancerous cells invade normal cells
and metastasize to distant sites with the help of the lymphatic system. There are several …

Fucoidan/hyaluronic acid cross-linked zein nanoparticles loaded with fisetin as a novel targeted nanotherapy for oral cancer

MA Moustafa, WM El-Refaie, YSR Elnaggar… - International Journal of …, 2023 - Elsevier
Fisetin (FS) is an anticancer drug having potential role in oral tumors management.
However, its clinical application is limited due to its hydrophobicity and instability. Bioactive …

The role of m6A RNA methylation in cancer: implication for nature products anti-cancer research

N Song, K Cui, K Zhang, J Yang, J Liu, Z Miao… - Frontiers in …, 2022 - frontiersin.org
N6-methyladenosine (m6A) RNA methylation is identified as the most common, abundant
and reversible RNA epigenetic modification in messenger RNA (mRNA) and non-coding …

Biotechnological applications and health-promoting properties of flavonols: An updated view

T Gervasi, A Calderaro, D Barreca, E Tellone… - International Journal of …, 2022 - mdpi.com
Flavonols are a subclass of natural flavonoids characterized by a remarkable number of
biotechnological applications and health-promoting properties. They attract researchers' …

[HTML][HTML] Fisetin inhibits the proliferation, migration and invasion of pancreatic cancer by targeting PI3K/AKT/mTOR signaling

Y Xiao, Y Liu, Z Gao, X Li, M Weng, C Shi… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Pancreatic cancer is an extremely malignant digestive tract tumor. With the increase of
chemotherapeutic resistance of pancreatic cancer, clinical treatment is in a dilemma. Hence …

In silico Study of Natural inhibitors for Human papillomavirus-18 E6 protein

A Proboningrat, VD Kharisma… - Research Journal of …, 2022 - indianjournals.com
Globally, the leading cause of death from cancer in women is infection with the human
papillomavirus (HPV). This calls for imperative actions to explore anticancer drugs against …

Targeting cancer stem cells by dietary agents: an important therapeutic strategy against human malignancies

M Deldar Abad Paskeh, S Asadi, A Zabolian… - International Journal of …, 2021 - mdpi.com
As a multifactorial disease, treatment of cancer depends on understanding unique
mechanisms involved in its progression. The cancer stem cells (CSCs) are responsible for …