Oligodendrocytes and astrocytes are macroglial cells of the vertebrate central nervous
system. These cells have diverse roles in the maintenance of neurological function. In the …

Hypomyelinating leukodystrophies constitute a subset of genetic white matter disorders
characterized by a primary lack of myelin deposition. Most patients with severe …

Injury to the preterm brain has a particular predilection for cerebral white matter. White
matter injury (WMI) is the most common cause of brain injury in preterm infants and a major …

Neonatally transplanted human glial progenitor cells (hGPCs) densely engraft and
myelinate the hypomyelinated shiverer mouse. We found that, in hGPC-xenografted mice …

Although major advances in the care of premature infants have resulted in striking
improvements in the survival of very low birth weight (VLBW) infants (< 1.5 kg), enhanced …

Myelin-related disorders such as multiple sclerosis and leukodystrophies, for which
restoration of oligodendrocyte function would be an effective treatment, are poised to benefit …

Background The present study evaluated the efficacy and safety of human embryonic stem
cell (hESC) therapy in patients with CP. Materials and methods This analysis included …

Background aims Cerebral palsy (CP) is related to severe perinatal hypoxia with permanent
brain damage in nearly 50% of surviving preterm infants. Cell therapy is a potential …

Hematopoietic stem cell transplantation (HSCT) has been used for three decades as therapy
for lysosomal storage diseases. Stable engraftment following transplantation has the …

Human neural stem cell transplants have potential as therapeutic candidates to treat a vast
number of disorders of the central nervous system (CNS). StemCells, Inc. has purified …