Adipose tissue at single-cell resolution
Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular
composition under physiological and pathophysiological conditions. The emergence of …
composition under physiological and pathophysiological conditions. The emergence of …
Challenges and opportunities to computationally deconvolve heterogeneous tissue with varying cell sizes using single-cell RNA-sequencing datasets
Deconvolution of cell mixtures in “bulk” transcriptomic samples from homogenate human
tissue is important for understanding disease pathologies. However, several experimental …
tissue is important for understanding disease pathologies. However, several experimental …
An integrated single cell and spatial transcriptomic map of human white adipose tissue
To date, single-cell studies of human white adipose tissue (WAT) have been based on small
cohort sizes and no cellular consensus nomenclature exists. Herein, we performed a …
cohort sizes and no cellular consensus nomenclature exists. Herein, we performed a …
Single-cell atlas of human infrapatellar fat pad and synovium implicates APOE signaling in osteoarthritis pathology
S Tang, L Yao, J Ruan, J Kang, Y Cao, X Nie… - Science Translational …, 2024 - science.org
The infrapatellar fat pad (IPFP) and synovium play essential roles in maintaining knee joint
homeostasis and in the progression of osteoarthritis (OA). The cellular and transcriptional …
homeostasis and in the progression of osteoarthritis (OA). The cellular and transcriptional …
Mapping human adult hippocampal neurogenesis with single-cell transcriptomics: reconciling controversy or fueling the debate?
The notion of exploiting the regenerative potential of the human brain in physiological aging
or neurological diseases represents a particularly attractive alternative to conventional …
or neurological diseases represents a particularly attractive alternative to conventional …
Studying stochastic systems biology of the cell with single-cell genomics data
Recent experimental developments in genome-wide RNA quantification hold considerable
promise for systems biology. However, rigorously probing the biology of living cells requires …
promise for systems biology. However, rigorously probing the biology of living cells requires …
Single-nucleus and bulk RNA sequencing reveal cellular and transcriptional mechanisms underlying lipid dynamics in high marbled pork
Pork is the most consumed meat in the world, and its quality is associated with human
health. Intramuscular fat (IMF) deposition (also called marbling) is a key factor positively …
health. Intramuscular fat (IMF) deposition (also called marbling) is a key factor positively …
Single cell genomics as a transformative approach for aquaculture research and innovation
Single cell genomics encompasses a suite of rapidly maturing technologies that measure
the molecular profiles of individual cells within target samples. These approaches provide a …
the molecular profiles of individual cells within target samples. These approaches provide a …
Length biases in single-cell RNA sequencing of pre-mRNA
Single-cell RNA sequencing data can be modeled using Markov chains to yield genome-
wide insights into transcriptional physics. However, quantitative inference with such data …
wide insights into transcriptional physics. However, quantitative inference with such data …
[HTML][HTML] Perspectives on single-nucleus RNA sequencing in different cell types and tissues
N Kim, H Kang, A Jo, SA Yoo… - Journal of Pathology …, 2023 - synapse.koreamed.org
Single-cell RNA sequencing has become a powerful and essential tool for delineating
cellular diversity in normal tissues and alterations in disease states. For certain cell types …
cellular diversity in normal tissues and alterations in disease states. For certain cell types …