The relevance of protein stability for biological function and molecular evolution is widely
recognized. Protein stability, however, comes in two flavours: thermodynamic stability, which …

Protein folding research stalled for decades because conventional experiments indicated
that proteins fold slowly and in single strokes, whereas theory predicted a complex interplay …

Single-molecule fluorescence spectroscopy and correlation methods are finding increasing
applications in the investigation of biomolecular dynamics, especially together with Förster …

Modern semiempirical electronic structure methods have considerable promise in drug
discovery as universal “force fields” that can reliably model biological and drug-like …

An extensive set of equilibrium and kinetic data is presented and analyzed for an ultrafast
folding protein—the villin subdomain. The equilibrium data consist of the excess heat …

The reconfigurable self-assembly of colloidal particles allows the bottom-up creation of
adaptive materials, yet significant challenges remain. Here, we demonstrate a synthesis of …

Protein folding mechanisms are probed experimentally using single-point mutant
perturbations. The relative effects on the folding (ϕ-values) and unfolding (1-ϕ) rates are …

β-Turns are common conformations that enable proteins to adopt globular structures, and
their formation is often rate limiting for folding. β-Turn mimics, molecules that replace the i+ 1 …

Differential scanning calorimetry (DSC) is a very powerful tool for investigating protein
folding and stability because its experimental output reflects the energetics of all …

Conspectus Proteins contain a level of complexity—secondary and tertiary structures—that
polymer chemists aim to imitate. The bottom-up synthesis of protein-mimicking polymers …