Numerous proteins are involved in the multiple pathways of the DNA damage response
network and play a key role to protect the genome from the wide variety of damages that can …

Telomerase negative immortal cancer cells elongate telomeres through the Alternative
Lengthening of Telomeres (ALT) pathway. While sustained telomeric replicative stress is …

Suppression of genomic instability is the key to prevent tumor development. PTEN is a
unique tumor suppressor protein having both lipid and protein phosphatase activities …

Co-transcriptional R loops arise from stalling of RNA polymerase, leading to the formation of
stable DNA: RNA hybrids. Unresolved R loops promote genome instability but are …

Fanconi anemia (FA) is a disease of DNA repair characterized by bone marrow failure and a
reduced ability to remove DNA interstrand cross-links. Here, we provide evidence that the …

DNA interstrand crosslinks (ICLs) are a physical barrier to replication and therefore toxic to
cell viability. An important mechanism for the removal of ICLs is the Fanconi Anemia DNA …

ABSTRACT PTEN phosphorylation at its C-terminal (C-tail) serine/threonine cluster
negatively regulates its tumor suppressor function. However, the consequence of such …

Phosphatase and tensin homolog (PTEN) is a tumor suppressor that directly regulates a
diverse array of cellular phenotypes, including growth, migration, morphology, and genome …

Fanconi anemia (FA) is an autosomal or X-linked human disease, characterized by bone
marrow failure, cancer susceptibility and various developmental abnormalities. So far, at …

Background Endometrial cancer (EC) arises from uterine endometrium tissue and is the
most prevalent cancer of the female reproductive tract in developed countries. It has been …