Redox processes are at the heart of synthetic methods that rely on either electrochemistry or
photoredox catalysis, but how do electrochemistry and photoredox catalysis compare? Both …

The progress of drug discovery and development is paced by milestones reached in organic
synthesis. In the last decade, the advent of late-stage functionalization (LSF) reactions has …

Sulfinates are important lynchpin intermediates in pharmaceutical production; however, their
synthesis via photoredox catalysis is challenging because of their facile oxidation. We …

INTRODUCTION The boronic acid is a functional group of enormous utility in materials
science, chemosensor development, and drug discovery. In medicinal chemistry, boronic …

The design of bioisosteres represents a creative and productive approach to improve a
molecule, including by enhancing potency, addressing pharmacokinetic challenges …

An emerging trend in small-molecule pharmaceuticals, generally composed of nitrogen
heterocycles (N-heterocycles), is the incorporation of aliphatic fragments. Derivatization of …

Despite being a clinically approved intervention for cancer, photodynamic therapy (PDT) still
suffers from limitations. Prime among these is a therapeutic response that is mostly oxygen …

Several kinds of anticancer drugs are presently commercially accessible, but low efficacy,
solubility, and toxicity have reduced the overall therapeutic indices. Thus, the search for …

Alkene aminoarylation with arylsulfonylacetamides via a visible light-mediated radical
Smiles–Truce rearrangement represents a convenient approach to the privileged …

The one-step conversion of aliphatic carboxylic acids to the corresponding nitriles has been
accomplished via the merger of visible light mediated photoredox and …