Options for the effective treatment of hereditary optic neuropathies have been a long time
coming. The successful launch of the antioxidant idebenone for Leber's Hereditary Optic …

Oligomycin has long been known as an inhibitor of mitochondrial ATP synthase, putatively
binding the F o subunits 9 and 6 that contribute to proton channel function of the complex. As …

Development of an increasingly detailed understanding of the eucaryotic mitochondrial ATP
synthase requires a detailed knowledge of the stoichiometry, structure and function of F0 …

J.-AS is supported by the Agence Nationale de la Recherche within the Programme
Investissements d'Avenir, Institut Hospitalo Universitaire FOReSIGHT (ANR-18-IAHU-0001) …

Allotopic expression is the functional transfer of an organellar gene to the nucleus, followed
by synthesis of the gene product in the cytosol and import into the appropriate organellar …

Allotopic expression of mitochondrial genes is a deliberate functional relocation of
mitochondrial genes into the nucleus followed by import of the gene-encoded polypeptide …

The yeast mitochondrial ATP synthase is a rotary molecular machine primarily responsible
for the production of energy used to drive cellular processes. The enzyme complex is …

Allotopic expression is potentially a gene therapy for mtDNA-related diseases. Some
OXPHOS proteins like ATP6 (subunit a of complex V) and COX3 (subunit III of complex IV) …

The past two decades have witnessed an evolving understanding of the mitochondrial
genome's (mtDNA) role in basic biology and disease. From the recognition that mutations in …

To study Bax-induced release of cytochrome c in vivo, we have expressed a cytochrome c–
GFP (green fluorescent protein) fusion in Saccharomyces cerevisiae cells null for the …