Doxorubicin resistance in breast cancer is mediated via the activation of FABP5/PPARγ and CaMKII signaling pathway

NN Chen, XD Ma, Z Miao, XM Zhang, BY Han… - Frontiers in …, 2023 - frontiersin.org
Breast cancer is the most prevalent malignancy among women. Doxorubicin (Dox)
resistance was one of the major obstacles to improving the clinical outcome of breast cancer …

Advances in understanding insect chitin biosynthesis

A Yu, M Beck, H Merzendorfer, Q Yang - Insect Biochemistry and Molecular …, 2023 - Elsevier
Chitin, a natural polymer of N-acetylglucosamine chains, is a principal component of the
apical extracellular matrix in arthropods. Chitin microfibrils serve as structural components of …

Fatty acid binding protein is required for chitin biosynthesis in the wing of Drosophila melanogaster

J Chen, X Zou, W Zhu, Y Duan, H Merzendorfer… - Insect Biochemistry and …, 2022 - Elsevier
Chitin, the major structural polysaccharide in arthropods such as insects and mites, is a
linear polymer of N-acetylglucosamine units. The growth and development of insects are …

Juvenile hormone biosynthetic genes are critical for regulating reproductive diapause in the cabbage beetle

Z Tian, S Guo, JX Li, F Zhu, W Liu, XP Wang - Insect Biochemistry and …, 2021 - Elsevier
In insects, the juvenile hormone (JH) biosynthetic pathway regulates the in vivo JH titer.
Thus, its downregulation potentially contributes to the lowering of JH titers typically observed …

The importance of fat accumulation and reserves for insect overwintering

T Enriquez, B Visser - Current Opinion in Insect Science, 2023 - Elsevier
Highlights•Most insects accumulate fat in preparation for winter.•Lipid accumulation and fat
stores are essential for insect overwintering.•Diapause and acclimation generally lead to …

Circadian clock genes link photoperiodic signals to lipid accumulation during diapause preparation in the diapause-destined female cabbage beetles Colaphellus …

L Zhu, Z Tian, S Guo, W Liu, F Zhu, XP Wang - Insect biochemistry and …, 2019 - Elsevier
Many organisms have evolved a series of adaptions, such as dormancy or diapause in
insects that enable them to withstand seasonally adverse conditions. In insects …

Targeting coat protein II complex genes via RNA interference inhibits female adult feeding and reproductive development in the cabbage beetle Colaphellus bowringi

Z Tian, S Guo, F Zhu, W Liu… - Pest Management …, 2022 - Wiley Online Library
BACKGROUND The cabbage beetle Colaphellus bowringi is a highly destructive
cruciferous vegetable pest in Asia. This beetle is predominantly controlled by synthetic …

A rapidly evolved shift in life‐history timing during ecological speciation is driven by the transition between developmental phases

THQ Powell, A Nguyen, Q Xia, JL Feder… - Journal of …, 2020 - academic.oup.com
For insect species in temperate environments, seasonal timing is often governed by the
regulation of diapause, a complex developmental programme that allows insects to weather …

Comparative Transcriptome and iTRAQ Proteome Analyses Reveal the Mechanisms of Diapause in Aphidius gifuensis Ashmead (Hymenoptera: Aphidiidae)

HZ Zhang, YY Li, T An, FX Huang, MQ Wang… - Frontiers in …, 2018 - frontiersin.org
Aphidius gifuensis Ashmead (Hymenoptera: Aphidiidae) is a solitary endoparasitoid used in
the biological control of various aphids. Diapause plays an important role in the successful …

Lipin modulates lipid metabolism during reproduction in the cabbage beetle

S Guo, Z Tian, F Zhu, W Liu, XP Wang - Insect Biochemistry and Molecular …, 2021 - Elsevier
Lipids are a critical source of stored energy in insects, and their metabolism is essential for
growth, development, and reproduction. Adequate provisioning of lipids and yolk proteins in …