COVID-19 vaccine update: vaccine effectiveness, SARS-CoV-2 variants, boosters, adverse effects, and immune correlates of protection
Abstract Coronavirus Disease 2019 (COVID-19) has been the most severe public health
challenge in this century. Two years after its emergence, the rapid development and …
challenge in this century. Two years after its emergence, the rapid development and …
Disentangling the relative importance of T cell responses in COVID-19: leading actors or supporting cast?
The rapid development of multiple vaccines providing strong protection from severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been a major achievement …
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been a major achievement …
Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2
The emerging SARS-CoV-2 variants of concern (VOCs) threaten the effectiveness of current
COVID-19 vaccines administered intramuscularly and designed to only target the spike …
COVID-19 vaccines administered intramuscularly and designed to only target the spike …
Pathogenesis of pneumonia and acute lung injury
ME Long, RK Mallampalli, JC Horowitz - Clinical Science, 2022 - portlandpress.com
Pneumonia and its sequelae, acute lung injury, present unique challenges for pulmonary
and critical care healthcare professionals, and these challenges have recently garnered …
and critical care healthcare professionals, and these challenges have recently garnered …
SARS-CoV-2-specific T cells in the changing landscape of the COVID-19 pandemic
Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, multiple severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with increasing ability to …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with increasing ability to …
SARS-CoV-2 mutations and their impact on diagnostics, therapeutics and vaccines
S Thakur, S Sasi, SG Pillai, A Nag, D Shukla… - Frontiers in …, 2022 - frontiersin.org
With the high rate of COVID-19 infections worldwide, the emergence of SARS-CoV-2
variants was inevitable. Several mutations have been identified in the SARS-CoV-2 …
variants was inevitable. Several mutations have been identified in the SARS-CoV-2 …
SARS-CoV-2-specific T cells in infection and vaccination
During viral infections, antibodies and T cells act together to prevent pathogen spread and
remove virus-infected cells. Virus-specific adaptive immunity can, however, also trigger …
remove virus-infected cells. Virus-specific adaptive immunity can, however, also trigger …
The T-cell-directed vaccine BNT162b4 encoding conserved non-spike antigens protects animals from severe SARS-CoV-2 infection
CM Arieta, YJ Xie, DA Rothenberg, H Diao, D Harjanto… - Cell, 2023 - cell.com
T cell responses play an important role in protection against beta-coronavirus infections,
including SARS-CoV-2, where they associate with decreased COVID-19 disease severity …
including SARS-CoV-2, where they associate with decreased COVID-19 disease severity …
The remarkable evolutionary plasticity of coronaviruses by mutation and recombination: insights for the COVID-19 pandemic and the future evolutionary paths of …
GD Amoutzias, M Nikolaidis, E Tryfonopoulou… - Viruses, 2022 - mdpi.com
Coronaviruses (CoVs) constitute a large and diverse subfamily of positive-sense single-
stranded RNA viruses. They are found in many mammals and birds and have great …
stranded RNA viruses. They are found in many mammals and birds and have great …
Cell surface SARS-CoV-2 nucleocapsid protein modulates innate and adaptive immunity
SARS-CoV-2 nucleocapsid protein (N) induces strong antibody (Ab) and T cell responses.
Although considered to be localized in the cytosol, we readily detect N on the surface of live …
Although considered to be localized in the cytosol, we readily detect N on the surface of live …