Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes
NJ Hogrebe, M Ishahak, JR Millman - Cell Stem Cell, 2023 - cell.com
The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs)
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …
Advances in islet encapsulation technologies
Type 1 diabetes is an autoimmune disorder in which the immune system attacks and
destroys insulin-producing islet cells of the pancreas. Although islet transplantation has …
destroys insulin-producing islet cells of the pancreas. Although islet transplantation has …
A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes
Transplantation of stem cell–derived β (SC-β) cells represents a promising therapy for type 1
diabetes (T1D). However, the delivery, maintenance, and retrieval of these cells remain a …
diabetes (T1D). However, the delivery, maintenance, and retrieval of these cells remain a …
Stem cell therapies for treating diabetes: progress and remaining challenges
Restoration of insulin independence and normoglycemia has been the overarching goal in
diabetes research and therapy. While whole-organ and islet transplantation have become …
diabetes research and therapy. While whole-organ and islet transplantation have become …
Advances in pancreatic islet transplantation sites for the treatment of diabetes
Diabetes is a complex disease that affects over 400 million people worldwide. The life-long
insulin injections and continuous blood glucose monitoring required in type 1 diabetes …
insulin injections and continuous blood glucose monitoring required in type 1 diabetes …
Hydrogels in emerging technologies for type 1 diabetes
Type 1 diabetes therapies that afford tighter glycemic control in a more manageable and
painless manner for patients has remained a central focus of next-generation diabetes …
painless manner for patients has remained a central focus of next-generation diabetes …
The journey of islet cell transplantation and future development
A Gamble, AR Pepper, A Bruni, AMJ Shapiro - Islets, 2018 - Taylor & Francis
Intraportal islet transplantation has proven to be efficacious in preventing severe
hypoglycemia and restoring insulin independence in selected patients with type 1 diabetes …
hypoglycemia and restoring insulin independence in selected patients with type 1 diabetes …
A retrievable implant for the long-term encapsulation and survival of therapeutic xenogeneic cells
The long-term function of transplanted therapeutic cells typically requires systemic immune
suppression. Here, we show that a retrievable implant comprising a silicone reservoir and a …
suppression. Here, we show that a retrievable implant comprising a silicone reservoir and a …
Encapsulated islets for diabetes therapy: history, current progress, and critical issues requiring solution
DW Scharp, P Marchetti - Advanced drug delivery reviews, 2014 - Elsevier
Insulin therapy became a reality in 1921 dramatically saving lives of people with diabetes,
but not protecting them from long-term complications. Clinically successful free islet implants …
but not protecting them from long-term complications. Clinically successful free islet implants …
[HTML][HTML] Enhancing longevity of immunoisolated pancreatic islet grafts by modifying both the intracapsular and extracapsular environment
Type 1 diabetes mellitus (T1DM) is a chronic metabolic disease characterized by
autoimmune destruction of pancreatic β cells. Transplantation of immunoisolated pancreatic …
autoimmune destruction of pancreatic β cells. Transplantation of immunoisolated pancreatic …