Parkinson's disease (PD) is one of the most common neurodegenerative disorders with a
global burden of approximately 6.1 million patients. Alpha-synuclein has been linked to both …

Parkinson's disease is a neurodegenerative disease/synucleinopathy that develops slowly;
however, there is no efficient method of early diagnosis, nor is there a cure. Progressive …

Abstract α-Synuclein (α-Syn) aggregation and amyloid formation is directly linked with
Parkinson's disease pathogenesis. However, the early events involved in this process …

The cell‐to‐cell transfer of α‐synuclein (α‐Syn) greatly contributes to Parkinson's disease
(PD) pathogenesis and underlies the spread of α‐Syn pathology. During this process …

Numerous pathological amyloid proteins spread from cell to cell during neurodegenerative
disease, facilitating the propagation of cellular pathology and disease progression …

As an intrinsically disordered protein, monomeric alpha-synuclein (aSyn) occupies a large
conformational space. Certain conformations lead to aggregation prone and non …

The accumulation of abnormal protein aggregates represents a universal hallmark of
neurodegenerative diseases (NDDs). Post-translational modifications (PTMs) regulate …

Stimulator of interferon genes (STING) is activated after detection of cytoplasmic dsDNA by
cGAS (cyclic GMP-AMP synthase) as part of the innate immunity defence against viral …

Intracellular accumulation of abnormal proteins with conformational changes is the defining
neuropathological feature of neurodegenerative diseases. The pathogenic proteins that …

Abstract Approximately 90% of alpha-synuclein (α-Synuclein) deposited in Lewy bodies is
phosphorylated at serine 129 suggesting that the accumulation of phosphorylated α …