Understanding normal and pathological hematopoietic stem cell biology using mathematical modelling

M Brunetti, MC Mackey, M Craig - Current Stem Cell Reports, 2021 - Springer
Abstract Purpose of Review Hematopoietic stem cells (HSCs) produce all blood cells via a
tightly controlled production system. Disruptions to control mechanisms can induce serious …

Aging, Inflammation, and Comorbidity in Cancers—A General In Silico Study Exemplified by Myeloproliferative Malignancies

JT Ottesen, M Andersen - Cancers, 2023 - mdpi.com
Simple Summary Cancer escape links to the insufficient immune response. Thus, transition
from a pre-cancerous state to cancerous development induced by morbidities competing for …

Multiplicity of time scales in blood cell formation and leukemia: Contributions of computational disease modeling to mechanistic understanding and personalized …

T Stiehl - Multiplicity of Time Scales in Complex Systems …, 2023 - Springer
Blood cell formation (hematopoiesis) is a complex and tightly regulated process. It is
maintained by hematopoietic (blood-forming) stem cells and serves as a paradigmatic …

A PDMP to model the stochastic influence of quiescence dynamics in blood cancers

C Bonnet - arXiv preprint arXiv:2303.06412, 2023 - arxiv.org
In this article, we will see a new approach to study the impact of a small microscopic
population of cancer cells on a macroscopic population of healthy cells, with an example …

Observer-based intelligent adaptive iterative time-varying controller for nonlinear of chronic myelogenous leukemia dynamics

R Ghasemi, BS Ghazanfarpour - International Journal of …, 2024 - ijnaa.semnan.ac.ir
An adaptive controller for a time-varying non-linear non-affine system is designed based on
the observer for chronic Myelogenous leukaemia (CML) as a blood cancer. Compared to …

[图书][B] Multiplicity of Time Scales in Complex Systems: Challenges for Sciences and Communication. I

B Booss - 2024 - books.google.com
This highly interdisciplinary volume brings together a carefully curated set of case studies
examining complex systems with multiple time scales (MTS) across a variety of fields …

Bayesian modeling and uncertainty quantification with applications in computed tomography and hemodialysis

KO Bangsgaard - 2023 - orbit.dtu.dk
In the healthcare system, a goal is to provide effective diagnosis and treatment to patients.
However, gaining a comprehensive understanding of the underlying mechanisms within the …