The 1013–1014 microorganisms present in the human gut (collectively known as the human
gut microbiota) dedicate substantial percentages of their genomes to the degradation and …

Alzheimer's Disease (AD) is a neurodegenerative brain disorder in which many biological
dysfunctions are involved. Among them, two main types of lesions were discovered and …

The addition of O-linked-β-DN-acetylglucosamine (O-GlcNAc) onto serine and threonine
residues of nuclear and cytoplasmic proteins is an abundant, unique post-translational …

Mucinolytic bacteria modulate host–microbiota symbiosis and dysbiosis through their ability
to degrade mucin O-glycans. However, how and to what extent bacterial enzymes are …

Pathological hyperphosphorylation of the microtubule-associated protein tau is
characteristic of Alzheimer's disease (AD) and the associated tauopathies. The reciprocal …

In order to accelerate the hydrolysis of glycosidic bonds by factors approaching 1017-fold,
glycosidases have evolved finely tuned active sites optimally configured for transition-state …

The chitinolytic machinery of S erratia marcescens is one of the best known enzyme systems
for the conversion of insoluble polysaccharides. This machinery includes four chitin‐active …

Insights into glycosidase mechanisms have come from X-ray crystallographic studies on
complexes with substrate analogs and inhibitors, representing all the intermediate species …

Alzheimer disease (AD) is a growing problem for aging populations worldwide. Despite
significant efforts, no therapeutics are available that stop or slow progression of AD, which …

Chitinase B (ChiB) from Serratia marcescens is a family 18 exo-chitinase whose catalytic
domain has a TIM-barrel fold with a tunnel-shaped active site. We have solved structures of …