Current perspective in the discovery of anti-aging agents from natural products

AJ Ding, SQ Zheng, XB Huang, TK Xing, GS Wu… - Natural products and …, 2017 - Springer
Aging is a process characterized by accumulating degenerative damages, resulting in the
death of an organism ultimately. The main goal of aging research is to develop therapies …

Unveiling the Longevity Potential of Natural Phytochemicals: A Comprehensive Review of Active Ingredients in Dietary Plants and Herbs

Y Wang, X Cao, J Ma, S Liu, X Jin… - Journal of Agricultural and …, 2024 - ACS Publications
Ancient humans used dietary plants and herbs to treat disease and to pursue eternal life.
Today, phytochemicals in dietary plants and herbs have been shown to be the active …

Temperature adaptations of the thermophilic snail Echinolittorina malaccana: insights from metabolomic analysis

Y Chen, J Wang, M Liao, X Li… - Journal of Experimental …, 2021 - journals.biologists.com
The periwinkle snail Echinolittorina malaccana, for which the upper lethal temperature is
near 55° C, is one of the most heat-tolerant eukaryotes known. We conducted a multi-level …

Global mapping of protein–metabolite interactions in Saccharomyces cerevisiae reveals that Ser-Leu dipeptide regulates phosphoglycerate kinase activity

M Luzarowski, R Vicente, A Kiselev, M Wagner… - Communications …, 2021 - nature.com
Protein–metabolite interactions are of crucial importance for all cellular processes but
remain understudied. Here, we applied a biochemical approach named PROMIS, to address …

[HTML][HTML] Sublethal toxicity of graphene oxide in Caenorhabditis elegans under multi-generational exposure

L Jin, TT Dou, JY Chen, MX Duan, Q Zhen… - Ecotoxicology and …, 2022 - Elsevier
Nanomaterials have received increasing attentions owing to their potential hazards to the
environment and human health; however, the multi-generational toxicity of graphene oxide …

The effects of active double-layered furcellaran/gelatin hydrolysate film system with Ala-Tyr peptide on fresh Atlantic mackerel stored at− 18 C

E Jamróz, P Kulawik, J Tkaczewska, P Guzik, M Zając… - Food Chemistry, 2021 - Elsevier
This is the first time that active double-layered furcellaran/gelatin hydrolysate films
containing Ala-Tyr peptide were developed and characterised for their properties …

Rosmarinic acid improved antioxidant properties and healthspan via the IIS and MAPK pathways in Caenorhabditis elegans

C Lin, J Xiao, Y Xi, X Zhang, Q Zhong, H Zheng… - …, 2019 - Wiley Online Library
Rosmarinic acid (RA) has a wide range of biological effects, including the antioxidation and
antiaging. However, the detailed mechanisms remain unclear but highly attractive. Herein …

Metabolomic shifts associated with heat stress in coral holobionts

A Williams, EN Chiles, D Conetta, JS Pathmanathan… - Science …, 2021 - science.org
Understanding the response of the coral holobiont to environmental change is crucial to
inform conservation efforts. The most pressing problem is “coral bleaching,” usually …

Anti-aging effect of sea cucumber (Cucumaria frondosa) hydrolysate on fruit flies and d-galactose-induced aging mice

L Lin, K Yang, L Zheng, M Zhao, W Sun, Q Zhu… - Journal of Functional …, 2018 - Elsevier
The search for treatment of aging and age-related diseases is a public health issue. Sea
cucumber (Cucumaria frondosa) hydrolysate (CFH) prepared by enzymatic hydrolysis and …

Tyr‐Asp inhibition of glyceraldehyde 3‐phosphate dehydrogenase affects plant redox metabolism

JC Moreno, BE Rojas, R Vicente, M Gorka… - The EMBO …, 2021 - embopress.org
How organisms integrate metabolism with the external environment is a central question in
biology. Here, we describe a novel regulatory small molecule, a proteogenic dipeptide Tyr …