SGLT-2 inhibitors and GLP-1 receptor agonists in metabolic dysfunction-associated fatty liver disease

JS Moon, JH Hong, YJ Jung, E Ferrannini… - Trends in Endocrinology …, 2022 - cell.com
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a chronic condition that
affects nearly one billion people globally, characterized by triacylglycerol accumulation in …

Obesity and endothelial function

M Kajikawa, Y Higashi - Biomedicines, 2022 - mdpi.com
Obesity is a major public health problem and is related to increasing rates of cardiovascular
morbidity and mortality. Over 1.9 billion adults are overweight or obese worldwide and the …

Effect of dulaglutide on liver fat in patients with type 2 diabetes and NAFLD: randomised controlled trial (D-LIFT trial)

MS Kuchay, S Krishan, SK Mishra, NS Choudhary… - Diabetologia, 2020 - Springer
Aims/hypothesis Liraglutide, a daily injectable glucagon-like peptide-1 receptor (GLP-1r)
agonist, has been shown to reduce liver fat content (LFC) in humans. Data regarding the …

[HTML][HTML] GLP-1 improves the supportive ability of astrocytes to neurons by promoting aerobic glycolysis in Alzheimer's disease

J Zheng, Y Xie, L Ren, L Qi, L Wu, X Pan, J Zhou… - Molecular …, 2021 - Elsevier
Objective Astrocytes actively participate in energy metabolism in the brain, and astrocytic
aerobic glycolysis disorder is associated with the pathology of Alzheimer's disease (AD) …

Liraglutide alleviates hepatic steatosis by activating the TFEB-regulated autophagy-lysosomal pathway

Y Fang, L Ji, C Zhu, Y Xiao, J Zhang, J Lu… - Frontiers in cell and …, 2020 - frontiersin.org
Liraglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), has been demonstrated
to alleviate non-alcoholic fatty liver disease (NAFLD). However, the underlying mechanism …

Obese mice weight loss role on nonalcoholic fatty liver disease and endoplasmic reticulum stress treated by a GLP-1 receptor agonist

RM Pontes-da-Silva, T de Souza Marinho… - International journal of …, 2022 - nature.com
Background/objectives The weight loss following Semaglutide treatment, a GLP-1 receptor
agonist, might be responsible for some effects observed on the nonalcoholic fatty liver …

Anti-inflammatory properties of antidiabetic drugs: a “promised land” in the COVID-19 era?

N Katsiki, E Ferrannini - Journal of Diabetes and its Complications, 2020 - Elsevier
Inflammation is implicated in the development and severity of the coronavirus disease 2019
(COVID-19), as well as in the pathophysiology of diabetes. Diabetes, especially when …

Clinical perspectives on the use of subcutaneous and oral formulations of semaglutide

B Gallwitz, F Giorgino - Frontiers in Endocrinology, 2021 - frontiersin.org
Early and effective glycemic control can prevent or delay the complications associated with
type 2 diabetes (T2D). The benefits of glucagon-like peptide-1 receptor agonists (GLP …

PRDM16 regulating adipocyte transformation and thermogenesis: a promising therapeutic target for obesity and diabetes

N Jiang, M Yang, Y Han, H Zhao, L Sun - Frontiers in pharmacology, 2022 - frontiersin.org
Given that obesity and diabetes have been major public health concerns and that disease
morbidities have been rising continuously, effective treatment for these diseases is urgently …

Endocrine disrupting chemicals: Friend or foe to brown and beige adipose tissue?

CE Francis, L Allee, H Nguyen, RD Grindstaff… - Toxicology, 2021 - Elsevier
Abstract The effects of Endocrine Disrupting Chemicals (EDCs) on the current obesity
epidemic is a growing field of interest. Numerous EDCs have shown the potential to alter …