A systematic assessment of global neural network connectivity through direct
electrophysiological assays has remained technically infeasible, even in simpler systems …

Human induced pluripotent stem cell (iPSC)-derived neurons are of interest for studying
neurological disease mechanisms, developing potential therapies and deepening our …

In situ physiological signals of in vitro neural disease models are essential for studying
pathogenesis and drug screening. Currently, an increasing number of in vitro neural disease …

It is known that cell density influences the maturation process of in vitro neuronal networks.
Neuronal cultures plated with different cell densities differ in number of synapses per neuron …

The CRISPR/Cas9 system is a rapid and customizable tool for gene editing in mammalian
cells. In particular, this approach has widely opened new opportunities for genetic studies in …

Spatially and temporally resolved delivery of soluble factors is a key feature for
pharmacological applications. In this framework, microfluidics coupled to multisite …

Local acidosis is associated with neuro-inflammation and can have significant effects in
several neurological disorders, including multiple sclerosis, brain ischemia, spinal cord …

In this study, we demonstrate capabilities to selectively manipulate dissociated co-cultures of
neurons plated in dual-compartment devices. Synaptic receptor antagonists and tetrodotoxin …

To address the issue of extracting useful information from large data-set of large scale
networks of neurons, we propose an algorithm that involves both algebraic-statistical and …

Multielectrode arrays (MEAs) can be used to capture electrophysiological activity of
neuronal cultures with high spatio-temporal resolution and have been successfully …