Reassessing B cell contributions in multiple sclerosis
There is growing recognition that B cell contributions to normal immune responses extend
well beyond their potential to become antibody-producing cells, including roles at the innate …
well beyond their potential to become antibody-producing cells, including roles at the innate …
[HTML][HTML] Memory B cells are major targets for effective immunotherapy in relapsing multiple sclerosis
Although multiple sclerosis (MS) is considered to be a CD4, Th17-mediated autoimmune
disease, supportive evidence is perhaps circumstantial, often based on animal studies, and …
disease, supportive evidence is perhaps circumstantial, often based on animal studies, and …
[HTML][HTML] Memory B cells activate brain-homing, autoreactive CD4+ T cells in multiple sclerosis
Multiple sclerosis is an autoimmune disease that is caused by the interplay of genetic,
particularly the HLA-DR15 haplotype, and environmental risk factors. How these etiologic …
particularly the HLA-DR15 haplotype, and environmental risk factors. How these etiologic …
[HTML][HTML] HLA-DR15 molecules jointly shape an autoreactive T cell repertoire in multiple sclerosis
The HLA-DR15 haplotype is the strongest genetic risk factor for multiple sclerosis (MS), but
our understanding of how it contributes to MS is limited. Because autoreactive CD4+ T cells …
our understanding of how it contributes to MS is limited. Because autoreactive CD4+ T cells …
B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS)
characterized by autoimmune-mediated demyelination and neurodegeneration. The CNS of …
characterized by autoimmune-mediated demyelination and neurodegeneration. The CNS of …
[HTML][HTML] Natalizumab in multiple sclerosis treatment: from biological effects to immune monitoring
K Khoy, D Mariotte, G Defer, G Petit… - Frontiers in …, 2020 - frontiersin.org
Multiple sclerosis is a chronic demyelinating disease of the central nervous system (CNS)
with an autoimmune component. Among the recent disease-modifying treatments available …
with an autoimmune component. Among the recent disease-modifying treatments available …
Myeloid cells—targets of medication in multiple sclerosis
Discussions of multiple sclerosis (MS) pathophysiology tend to focus on T cells and B cells
of the adaptive immune response. The innate immune system is less commonly considered …
of the adaptive immune response. The innate immune system is less commonly considered …
B cells and antibodies in multiple sclerosis pathogenesis and therapy
M Krumbholz, T Derfuss, R Hohlfeld… - Nature Reviews …, 2012 - nature.com
B cells and antibodies account for the most prominent immunodiagnostic feature in patients
with multiple sclerosis (MS), namely oligoclonal bands. Furthermore, evidence is …
with multiple sclerosis (MS), namely oligoclonal bands. Furthermore, evidence is …
Current multiple sclerosis treatments have improved our understanding of MS autoimmune pathogenesis
Multiple sclerosis (MS) is the most common inflammatory disorder of the central nervous
system (CNS) in young adults. When MS is not treated, it leads to irreversible and severe …
system (CNS) in young adults. When MS is not treated, it leads to irreversible and severe …
[HTML][HTML] B cells are multifunctional players in multiple sclerosis pathogenesis: insights from therapeutic interventions
N Claes, J Fraussen, P Stinissen, R Hupperts… - Frontiers in …, 2015 - frontiersin.org
Multiple sclerosis (MS) is a severe disease of the central nervous system (CNS)
characterized by autoimmune inflammation and neurodegeneration. Historically, damage to …
characterized by autoimmune inflammation and neurodegeneration. Historically, damage to …