Myosins constitute a large superfamily of actin-dependent molecular motors. Phylogenetic
analysis currently places myosins into 15 classes. The conventional myosins which form …

In the past few years genetic, biochemical, and cytolocalization data have implicated
members of the myosin superfamily of actin-based molecular motors in a variety of cellular …

Myosins and kinesins are molecular motors that hydrolyse ATP to track along actin filaments
and microtubules, respectively. Although the kinesin family includes motors that move …

The mouse represents an excellent model system for the study of genetic deafness in
humans. Many mouse deafness mutants have been identified and the anatomy of the mouse …

Myosin VI is a molecular motor involved in intracellular vesicle and organelle transport. To
carry out its cellular functions myosin VI moves toward the pointed end of actin, backward in …

The early Drosophila embryo undergoes two distinct membrane invagination events
believed to be mechanistically related to cytokinesis: metaphase furrow formation and …

The mouse shaker-1 locus, Myo7a, encodes myosin VIIA and mutations in the orthologous
gene in humans cause Usher syndrome type 1B or non-syndromic deafness. Myo7a is …

Many cellular components are transported using a combination of the actin-and microtubule-
based transport systems. However, how these two systems work together to allow well …

Neurons transport and position mitochondria using a combination of saltatory, bidirectional
movements and stationary docking. Axonal mitochondria move along microtubules (MTs) …

The mouse mutant Snell's waltzer (sv) has an intragenic deletion of the Myo6 gene, which
encodes the unconventional myosin molecule myosin VI (KB Avraham et al., 1995, Nat …