Mechanisms of genomic instability in breast cancer

PHG Duijf, D Nanayakkara, K Nones, S Srihari… - Trends in molecular …, 2019 - cell.com
Breast cancer is the most common cancer among women globally. Genomic instability (GI)
refers to the increased tendency to accrue genomic alterations. It drives heterogeneity and is …

Comparative efficacy and acceptability of pharmaceutical management for adults with post-traumatic stress disorder: a systematic review and meta-analysis

ZD Huang, YF Zhao, S Li, HY Gu, LL Lin… - Frontiers in …, 2020 - frontiersin.org
The current clinical guidelines on post-traumatic stress disorder (PTSD) recommend
selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake …

Pan-cancer analysis connects tumor matrisome to immune response

SB Lim, MLK Chua, JPS Yeong, SJ Tan, WT Lim… - NPJ precision …, 2019 - nature.com
Recent sequencing efforts unveil genomic landscapes of tumor microenvironment. A key
compartment in this niche is the extracellular matrix (ECM) and its related components …

Centromere protein I (CENP-I) is upregulated in gastric cancer, predicts poor prognosis, and promotes tumor cell proliferation and migration

J Wang, X Liu, H Chu, N Li… - Technology in Cancer …, 2021 - journals.sagepub.com
This study aimed to investigate the expression and cellular function of the centromeric family
of proteins (CENPs), especially centromere protein I (CENP-I), in gastric cancer (GC) and …

hSSB1 (NABP2/OBFC2B) modulates the DNA damage and androgen‐induced transcriptional response in prostate cancer

MN Adams, LV Croft, A Urquhart, MAM Saleem… - The …, 2023 - Wiley Online Library
Background Activation and regulation of androgen receptor (AR) signaling and the DNA
damage response impact the prostate cancer (PCa) treatment modalities of androgen …

Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy

K Kildey, NS Gandhi, KB Sahin, ET Shah… - Communications …, 2021 - nature.com
Platinum-based chemotherapy remains the cornerstone of treatment for most non-small cell
lung cancer (NSCLC) cases either as maintenance therapy or in combination with …

Downregulation of miR‐146a promotes cell migration in Helicobacter pylori–negative gastric cancer

N Shomali, N Shirafkan, PHG Duijf… - Journal of cellular …, 2019 - Wiley Online Library
Abstract microRNAs (miRs) are short noncoding RNAs that post‐transcriptionally suppress
gene expression. miR‐146a acts as an oncogene or a tumor suppressor in various cancers …

Correlation between Vaginal Microecological Status and Prognosis of CIN Patients with High‐Risk HPV Infection

H Zhang, S Jin, A Ji, C Zhang… - BioMed Research …, 2022 - Wiley Online Library
Many microorganisms live in the vagina of healthy women. They interact with and compete
with the microenvironment in the female vagina to form a dynamic balance of the …

Contradictory mRNA and protein misexpression of EEF1A1 in ductal breast carcinoma due to cell cycle regulation and cellular stress

CY Lin, A Beattie, B Baradaran, E Dray, PHG Duijf - Scientific reports, 2018 - nature.com
Encoded by EEF1A1, the eukaryotic translation elongation factor eEF1α1 strongly promotes
the heat shock response, which protects cancer cells from proteotoxic stress, following for …

Cep55 overexpression promotes genomic instability and tumorigenesis in mice

D Sinha, P Nag, D Nanayakkara, PHG Duijf… - Communications …, 2020 - nature.com
High expression of centrosomal protein CEP55 has been correlated with clinico-
pathological parameters across multiple human cancers. Despite significant in vitro studies …