Burkholderia pseudomallei and Burkholderia mallei vaccines: Are we close to clinical trials?

RW Titball, MN Burtnick, GJ Bancroft, P Brett - Vaccine, 2017 - Elsevier
B. pseudomallei is the cause of melioidosis, a serious an often fatal disease of humans and
animals. The closely related bacterium B. mallei, which cases glanders, is considered to be …

Recent advances in lipopolysaccharide-based glycoconjugate vaccines

H Zhu, CS Rollier, AJ Pollard - Expert Review of Vaccines, 2021 - Taylor & Francis
Introduction The public health burden caused by pathogenic Gram-negative bacteria is
increasingly prominent due to antimicrobial resistance. The surface carbohydrates are …

Intranasal immunization with a Bucl8-based vaccine ameliorates bacterial burden and pathological inflammation, and promotes an IgG2a/b dominant response in an …

M Grund, SJ Choi, L Powell, S Lukomski - Frontiers in Immunology, 2023 - frontiersin.org
Burkholderia pseudomallei is a gram-negative bacterium that is the etiological agent of the
tropical disease melioidosis. Currently, there is no licensed vaccine for melioidosis, but …

Deciphering minimal antigenic epitopes associated with Burkholderia pseudomallei and Burkholderia mallei lipopolysaccharide O-antigens

M Tamigney Kenfack, M Mazur, T Nualnoi… - Nature …, 2017 - nature.com
Abstract Burkholderia pseudomallei (Bp) and Burkholderia mallei (Bm), the etiologic agents
of melioidosis and glanders, respectively, cause severe disease in both humans and …

Polysaccharides from Burkholderia species as targets for vaccine development, immunomodulation and chemical synthesis

M Cloutier, K Muru, G Ravicoularamin… - Natural product …, 2018 - pubs.rsc.org
Covering: up to 2018 Burkholderia species are a vast group of human pathogenic,
phytopathogenic, and plant-or environment-associated bacteria. B. pseudomallei, B. mallei …

Burkholderia pseudomallei Complex Subunit and Glycoconjugate Vaccines and Their Potential to Elicit Cross-Protection to Burkholderia cepacia Complex

AJ Badten, AG Torres - Vaccines, 2024 - mdpi.com
Burkholderia are a group of Gram-negative bacteria that can cause a variety of diseases in
at-risk populations. B. pseudomallei and B. mallei, the etiological agents of melioidosis and …

Serotype switching in Pseudomonas aeruginosa ST111 enhances adhesion and virulence

M Anbo, MA Lubna, DA Moustafa, TO Paiva… - PLoS …, 2024 - journals.plos.org
Evolution of the highly successful and multidrug resistant clone ST111 in Pseudomonas
aeruginosa involves serotype switching from O-antigen O4 to O12. How expression of a …

A bivalent vaccine derived from attenuated Salmonella expressing O-antigen polysaccharide provides protection against avian pathogenic Escherichia coli O1 and O2 …

Y Han, Q Liu, S Willias, K Liang, P Li, A Cheng, Q Kong - Vaccine, 2018 - Elsevier
Avian pathogenic Escherichia coli (APEC), a leading cause of avian airsacculitis and
colibacillosis, is responsible for significant economic loss in the poultry industry. APEC …

[HTML][HTML] Recombinant Live-Attenuated Salmonella Vaccine for Veterinary Use

DB Chagas, FDS Santos, NR de Oliveira, TLO Bohn… - Vaccines, 2024 - mdpi.com
Vaccination is essential for maintaining animal health, with priority placed on safety and cost
effectiveness in veterinary use. The development of recombinant live-attenuated Salmonella …

Melioidosis and glanders modulation of the innate immune system: barriers to current and future vaccine approaches

SA Aschenbroich, ER Lafontaine… - Expert review of …, 2016 - Taylor & Francis
Burkholderia pseudomallei and Burkholderia mallei are pathogenic bacteria causing fatal
infections in animals and humans. Both organisms are classified as Tier 1 Select Agents …