Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved
serine/threonine protein kinase encoded in mammals by two genes that generate two …

Glycogen synthase kinase-3β (GSK3β) is a fascinating enzyme with an astoundingly diverse
number of actions in intracellular signaling systems. GSK3β activity is regulated by serine …

Abstract Glycogen synthase kinase-3 (GSK-3) is an unusual protein-serine kinase in that it is
primarily regulated by inhibition and lies downstream of multiple cell signaling pathways …

Abstract Glycogen synthase kinase-3 (GSK3) was initially identified more than two decades
ago as an enzyme involved in the control of glycogen metabolism. In recent years it has …

beta-Amyloid precursor protein (beta-APP), the source of the fibrillogenic amyloid beta-
peptide (A beta) that accumulates in the brain of victims of Alzheimer's disease, is a …

Nearly 100 proteins are proposed to be substrates for GSK3, suggesting that this enzyme is
a fundamental regulator of almost every process in the cell, in every tissue in the body …

Lithium salts have been in the therapeutic toolbox for better or worse since the 19th century,
with purported benefit in gout, hangover, insomnia, and early suggestions that lithium …

Alzheimer's disease (AD), the most common neurodegenerative disorder, is the leading
cause of dementia. Neuritic plaque, one of the major characteristics of AD neuropathology …

The accumulation of β-amyloid (Aβ) peptide derived from abnormal processing of amyloid
precursor protein (APP) is a common pathological hallmark of Alzheimer's disease (AD) …

Amyloid-β peptide (Aβ) aggregate in senile plaque is a key characteristic of Alzheimer's
disease (AD). Here, we show that phosphorylation of amyloid precursor protein (APP) on …