Therapeutic siRNA: state of the art

B Hu, L Zhong, Y Weng, L Peng, Y Huang… - Signal transduction and …, 2020 - nature.com
ABSTRACT RNA interference (RNAi) is an ancient biological mechanism used to defend
against external invasion. It theoretically can silence any disease-related genes in a …

siRNA delivery strategies: a comprehensive review of recent developments

K Tatiparti, S Sau, SK Kashaw, AK Iyer - Nanomaterials, 2017 - mdpi.com
siRNA is a promising therapeutic solution to address gene overexpression or mutations as a
post-transcriptional gene regulation process for several pathological conditions such as viral …

Drosophila tools and assays for the study of human diseases

B Ugur, K Chen, HJ Bellen - Disease models & mechanisms, 2016 - journals.biologists.com
Many of the internal organ systems of Drosophila melanogaster are functionally analogous
to those in vertebrates, including humans. Although humans and flies differ greatly in terms …

Delivery materials for siRNA therapeutics

R Kanasty, JR Dorkin, A Vegas, D Anderson - Nature materials, 2013 - nature.com
RNA interference (RNAi) has broad potential as a therapeutic to reversibly silence any gene.
To achieve the clinical potential of RNAi, delivery materials are required to transport short …

The cell biology of renal filtration

RP Scott, SE Quaggin - Journal of cell biology, 2015 - rupress.org
The function of the kidney, filtering blood and concentrating metabolic waste into urine, takes
place in an intricate and functionally elegant structure called the renal glomerulus. Normal …

Diabetes‐induced reactive oxygen species: mechanism of their generation and role in renal injury

S Fakhruddin, W Alanazi… - Journal of diabetes …, 2017 - Wiley Online Library
Diabetes induces the onset and progression of renal injury through causing hemodynamic
dysregulation along with abnormal morphological and functional nephron changes. The …

Basement membranes: cell scaffoldings and signaling platforms

PD Yurchenco - Cold Spring Harbor perspectives in …, 2011 - cshperspectives.cshlp.org
Basement membranes are widely distributed extracellular matrices that coat the basal
aspect of epithelial and endothelial cells and surround muscle, fat, and Schwann cells …

Strategies for extended serum half-life of protein therapeutics

RE Kontermann - Current opinion in biotechnology, 2011 - Elsevier
With a growing number of protein therapeutics being developed, many of them exhibiting a
short plasma half-life, half-life extension strategies find increasing attention by the biotech …

[HTML][HTML] Properties of the glomerular barrier and mechanisms of proteinuria

B Haraldsson, J Nyström, WM Deen - Physiological reviews, 2008 - journals.physiology.org
This review focuses on the intricate properties of the glomerular barrier. Other reviews have
focused on podocyte biology, mesangial cells, and the glomerular basement membrane …

A potential role for mechanical forces in the detachment of podocytes and the progression of CKD

W Kriz, KV Lemley - Journal of the American Society of …, 2015 - journals.lww.com
Loss of podocytes underlies progression of CKD. Detachment of podocytes from the
glomerular basement membrane (GBM) rather than apoptosis or necrosis seems to be the …