In this review, we summarize the current knowledge about the membranous replication
factories of members of plus-strand (+) RNA viruses. We discuss primarily the architecture of …

Plus-strand RNA virus replication occurs in tight association with cytoplasmic host cell
membranes. Both, viral and cellular factors cooperatively generate distinct organelle-like …

Positive strand RNA viruses replicate in the cytoplasm of infected cells and induce
intracellular membranous compartments harboring the sites of viral RNA synthesis. These …

Replication and assembly of many viruses occur in specific intracellular compartments
known as 'virus factories'. Our knowledge of the biogenesis and architecture of these unique …

Viral factories are novel structures built by viruses in infected cells. During their construction
organelles are recruited and build a large scaffold for viral replication and morphogenesis …

Viruses recruit cellular membranes and subvert cellular proteins involved in lipid
biosynthesis to build viral replicase complexes and replication organelles. Among the lipids …

Assembling of the membrane-bound viral replicase complexes (VRCs) consisting of viral-
and host-encoded proteins is a key step during the replication of positive-stranded RNA …

Highlights•(+) RNA virus replication compartments form two structural classes.•Both classes
of replication compartments use cellular membrane curvature proteins.•Both classes of …

Mammalian orthoreoviruses (reoviruses) are nonenveloped viruses that replicate in
cytoplasmic membranous organelles called viral inclusions (VIs) where progeny virions are …

Background Hfq is a bacterial protein involved in several aspects of nucleic acid
transactions, but one of its best-characterized functions is to affect the post-transcriptional …